Skip to content
Peptigraph home
Shop Peptides50% off*

Selank Nasal Spray: What Studies Show

Which studies gave Selank as a nasal spray form, what they measured, and what is approved. No product recommendations.

Medical review pendingTuftsin analogUpdated
Route
nasal spray
FDA-approved product for this route
None
Route studies (human / animal)
0 / 3
in our evidence file (PubMed search, 11 Oct 2026)

Studies that gave Selank nasal spray

Each row is a study whose stated route matches. Animal and cell results are labelled and are not human results.

Selank studies by nasal spray route
StudyDesignnDoseFirst outcome
Eksperimental'naia i klinicheskaia farmakologiia 2016, PMID 29787664Animal · mouse (not a human result)Not stated300 μg/kg/dayAnxiolytic and nootropic effect by route: Both intranasal and intraperitoneal selank worked only in the more anxious BALB/c strain.
Zhurnal evoliutsionnoi biokhimii i fiziologii 2008, PMID 18727417Animal · monkey (not a human result)Not statedNot statedFear and aggression: Intranasal selank produced long-term behavioural improvement in neurotic monkeys, including elimination of fear and aggression.
Bioorganicheskaia khimiia 2006, PMID 16637290Animal · rat (in vivo and in vitro blood plasma) (not a human result)Not statedNot statedBiodegradation products: Selank is broken down mainly into the pentapeptide TKPRP, tripeptide TKP and dipeptides RP and GP.

For the injected form, see Selank dosage and Selank half-life.

Studies that used the intranasal route

In monkeys with induced neurosis, intranasal selank was reported to eliminate fear and aggression and to raise orientational-explorative activity over the long term.[2]

Mice received selank at 300 μg/kg/day for 5 days either intranasally or intraperitoneally and were tested on the elevated plus maze.[1]

By the nasal route selank raised [G-(3)H]MK-801 binding sites by 23% with no effect on GABA receptors; this is mouse brain data.[1]

By the intraperitoneal route selank instead raised GABA-receptor binding sites in the frontal cortex by 38% without changing NMDA binding in the hippocampus; this is mouse brain data.[1]

A tritium-labelling study followed intranasally administered selank into brain tissue in animals and identified the breakdown products TKPRP, TKP, RP and GP.[3]

Absorption versus injection, and the human gap

None of the 4 cached human selank abstracts mentions a nasal route, so the number of human studies of intranasal selank in the sources is 0.

Calculated from abstracts checked 18454096, 26356395, 25176261, 18577961; term nasal; abstracts mentioning nasal 0. Formula: count of abstracts mentioning the term = 0

No bioavailability or plasma concentration value for nasal selank appears in the cached abstracts; the pharmacokinetic work reports degradation products only.

Calculated from abstracts with nasal bioavailability value 0; pharmacokinetic abstract 16637290. Formula: count = 0

Safety by route

The only safety wording on selank in the cached mechanism paper is that it does not cause side effects typical of most anxiolytics, with no route-specific adverse-event data.[4]

Common questions

Is there an FDA-approved nasal spray form of Selank?

We found no FDA-approved nasal spray product for Selank in our evidence file. Products sold as nasal spray forms are not checked by the FDA.

Have studies given Selank as a nasal spray form?

3 studies in our evidence file gave Selank by a nasal spray route: 0 in people and 3 in animals.

Does selank nasal spray work?

In mice, nasal and intraperitoneal selank both showed anxiolytic and nootropic efficiency, but only in BALB/c mice; no human nasal trial is cached.[1]

More on Selank

DosageDoses used in published studies, with the source for each.CalculatorVial, water and dose to syringe units.Side effectsWhat labels and studies report, and what is unknown.ResultsStudy outcomes and when they were measured.BenefitsClaimed benefits next to what published studies measured.How it worksTarget, mechanism and how long it acts, from the label or studies.

Sources

  1. 1[COMPARISON OF PHARMACOLOGICAL EFFECTS OF HEPTAPEPTIDE SELANK AFTER INTRANASAL AND INTRAPERITONEAL ADMINISTRATION TO BALB/c AND C57BL/6 MICE.].Eksperimental'naia i klinicheskaia farmakologiia · 2016PMID 29787664Accessed 2 Oct 2026
  2. 2[Compensatory and antiamnestic effects of heptapeptide Selank in monkeys].Zhurnal evoliutsionnoi biokhimii i fiziologii · 2008PMID 18727417Accessed 2 Oct 2026
  3. 3[Evenly tritium-labeled peptides and their in vivo and in vitro biodegradation].Bioorganicheskaia khimiia · 2006PMID 16637290Accessed 2 Oct 2026
  4. 4The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity.Bulletin of experimental biology and medicine · 2001PMID 11550013Accessed 2 Oct 2026

Found an error? Report a correction.