5-Amino-1MQ Results: What Studies Measured and When
What published studies measured for 5-Amino-1MQ, when those outcomes were measured, and what is still unproven.
What studies measured
Each outcome below comes from a published study, with its type and size, strongest design first. Animal and cell results are labelled as such and are not human results.
| Outcome | Result | Study type | Source |
|---|---|---|---|
| Adiposity and weight loss with low-fat diet | In diet-induced obese mice, 5-amino-1-methylquinolinium combined with a low-fat diet promoted marked loss of adiposity and weight, normalising them to lean animals, which the diet switch alone did not do. | Animal · mouse (not a human result) | Scientific reports 2022, PMID 35013352 |
| Cancer cell viability | NNMT inhibitors reduced viability, increased reactive oxygen species and activated apoptosis in osteosarcoma and Merkel cell carcinoma cells in culture. | In vitro (not a human result) | Biomolecules 2025, PMID 41301471 |
| Cell proliferation | 5MQ inhibited HeLa cervical cancer cell proliferation without apparently affecting HEK-293 cells in culture. | In vitro (not a human result) | Journal of obstetrics and gynaecology 2021, PMID 33645410 |
| NNMT inhibition by quinolinium scaffold | Quinolinium analogues were identified as a promising NNMT-inhibitor scaffold with IC50 of about 1 μM in enzyme assays. | In vitro (not a human result) | Journal of medicinal chemistry 2017, PMID 28548833 |
- No human studies of 5-amino-1MQ have been published in PubMed as of 2 October 2026. The evidence is one diet-induced obese mouse study and cell or enzyme work in non-obesity settings. No dose, route or timeline can be taken from human data.
- 5-amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule NNMT inhibitor, not a peptide, and is not FDA-approved. Some sources call it '5MQ', and naming is inconsistent in the literature, so only studies that clearly name 5-amino-1-methylquinolinium were used. The compound identity in one cited paper (PMID 33645410) is uncertain.
- The obesity mouse paper (PMID 35013352) is a microbiome study; the weight-loss effect comes from combining the inhibitor with a diet switch.
- No pharmacokinetic or stability data were found. There are no data for any goal other than weight loss and metabolism, and those are animal-only.
Typical timeline
When measurable changes appeared in studies of 5-Amino-1MQ: not reported in study abstracts (PubMed search, 2 Oct 2026).
Before-and-after photos
We don't publish before-and-after photos. They can't be verified, rarely show dose, diet or other drugs, and only the most dramatic results get posted.
Common questions
How long does 5-Amino-1MQ take to work?
The study abstracts we summarised for 5-Amino-1MQ do not report when outcomes were measured (PubMed search, 2 Oct 2026).
Do you show 5-Amino-1MQ before and after photos?
No. Photos can't be verified, rarely show dose, diet or other drugs, and only the most dramatic ones get posted. We summarize measured outcomes instead.
More on 5-Amino-1MQ
DosageDoses used in published studies, with the source for each.CalculatorVial, water and dose to syringe units.Side effectsWhat labels and studies report, and what is unknown.PricePrice per mg and per week from dated listings. No vendor links.For weight lossWhat research says about 5-Amino-1MQ for weight loss.
Sources
- 1Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice.Scientific reports · 2022PMID 35013352Accessed 2 Oct 2026
- 2Small Molecule Inhibitors of Nicotinamide N-Methyltransferase Enzyme for the Treatment of Osteosarcoma and Merkel Cell Carcinoma: Potential for the Development of a Targeted Therapeutic Strategy.Biomolecules · 2025PMID 41301471Accessed 2 Oct 2026
- 3Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells.Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 2021PMID 33645410Accessed 2 Oct 2026
- 4Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase.Journal of medicinal chemistry · 2017PMID 28548833Accessed 2 Oct 2026
- 5PubMed search: "5-amino-1MQ"[tiab] OR "5-amino-1-methylquinolinium"[tiab] (3 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
- 6PubMed search: nicotinamide N-methyltransferase[tiab] AND (quinolinium[tiab] OR 5-amino-1MQ[tiab] OR "5-amino-1-methylquinolinium"[tiab] OR 5MQ[tiab]) (6 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
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