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DSIP

Sleep peptide. DSIP is not FDA approved for any use.

Also called:delta sleep-inducing peptideemideltide
Medically reviewed by Juan Pablo Frías, MD · · DisclosureUpdated Strongest evidence: Human RCT evidence, 4 of 4
StatusPCAC did not recommend (Jul 2026)Removed from FDA Category 2 on 15 Apr 2026. PCAC did not recommend for the 503A list (Jul 2026).WADA status unclearFull legal history

Key facts

How we verify
Class
Sleep peptide
Also called
delta sleep-inducing peptide, emideltide
Vial sizes sold
2 mg, 5 mg, 10 mg
Community-reported sizes
Half-life
4.0 +/- 0.7 min
intravenous, dog · Neuroendocrinology 1984, PMID 6379493
FDA status
Not approved
Off Category 2, 15 Apr 2026
PCAC vote
Not recommended
Jul 2026, not final
WADA
Unclear
Not named on the 2026 list
Everything on DSIP

DSIP guides

DosageDoses used in published studies, with the source for each.Side effectsWhat labels and studies report, and what is unknown.CalculatorVial, water and dose to syringe units.ResultsStudy outcomes and when they were measured.PricePrice per mg and per week from dated listings. No vendor links.For sleepWhat research says about DSIP for sleep.

Evidence at a glance

Human and animal counts are PubMed records from our evidence ledger (search counts, not studies we reviewed). The grade is the strongest design among the studies we summarised for that goal: a human randomized trial outweighs any number of animal studies.

DSIP: studies by condition
ConditionHuman studiesAnimal studiesStudies we summarisedEvidence grade
Sleep763069Human RCT evidence, 4 of 4European journal of anaesthesiology 2009, PMID 19142086

Grades follow our evidence scale. Summarised studies come from our evidence file, each quote checked against the abstract or label.

Common questions

Is DSIP FDA approved?

No. DSIP is not FDA approved for any use. The FDA removed it from Category 2 on 15 Apr 2026. Its advisory committee did not recommend it for the 503A compounding list in July 2026.

How much water goes in a 10 mg vial?

That choice only changes the concentration. With 2 mL, the vial is 5 mg/mL. The calculator converts any amount to syringe units. It does the math only and does not suggest a dose.

Sources

  1. 1Certain bulk drug substances for use in compounding that may present significant safety risks (Category 2; 'nominated but withdrawn' table, content current as of 22 Apr 2026)U.S. Food and Drug Administration · 2026fda.govAccessed 2 Oct 2026
  2. 2Pharmacy Compounding Advisory Committee meeting, 23–24 Jul 2026 (agenda and materials)U.S. Food and Drug Administration · 2026fda.govAccessed 2 Oct 2026
  3. 3US search volume and year-over-year trend, Google Keyword Planner export (Jun–Aug 2026 vs 2025)Peptigraph research · 2026peptigraph.com/methodology/Accessed 1 Oct 2026
  4. 4World Anti-Doping Code International Standard Prohibited List 2026World Anti-Doping Agency · 2026wada-ama.orgAccessed 2 Oct 2026
  5. 5United States: No FDA-approved product found: Drugs@FDA (openFDA) search for active ingredient "DSIP" returned no matches on 2 Oct 2026.U.S. Food and Drug Administration · 2026api.fda.govAccessed 2 Oct 2026
  6. 6US compounding: DSIP (emideltide) was removed from FDA's 503A category 2 after the nominators withdrew; FDA announced a PCAC consultation on 24 July 2026.U.S. Food and Drug Administration · 2026fda.govAccessed 2 Oct 2026
  7. 7Delta sleep-inducing peptide alters bispectral index, the electroencephalogram and heart rate variability when used as an adjunct to isoflurane anaesthesia.European journal of anaesthesiology · 2009PMID 19142086Accessed 2 Oct 2026
  8. 8Development of an enzyme immunoassay for delta sleep-inducing peptide (DSIP) and its use in the determination of the metabolic clearance rate of DSIP administered to dogs.Neuroendocrinology · 1984PMID 6379493Accessed 2 Oct 2026
  9. 9Advisory committee backs 6 of 7 peptides for the 503A listNCPA · 2026ncpa.org
  10. 10FDA gives notice that 12 peptides will be removed from Category 2 (nominations withdrawn)FDA · 2026fda.govAccessed 2 Oct 2026

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