Does selank make you tired?
In a trial comparing selank with medazepam in patients with anxiety and neurasthenia, selank was described as having antiasthenic and psychostimulant effects, with anxiolytic effects similar to medazepam. That points away from tiredness, though it is a description of effects, not a count of side effects.
Short answer
In a trial comparing selank with medazepam in patients with anxiety and neurasthenia, selank was described as having antiasthenic and psychostimulant effects, with anxiolytic effects similar to medazepam. That points away from tiredness, though it is a description of effects, not a count of side effects.[1]
A laboratory study of the peptide says it attenuates anxiety and does not cause side effects typical of most anxiolytics.[2]
Selank added to a benzodiazepine
When selank was added to phenazepam, side effects of the tranquilizer, including asthenia and sedation, were lower than with phenazepam alone.[3]
That comparison split patients between phenazepam alone (30) and the combination (40), and it measures the benzodiazepine's side effects, not selank's own.[3]
Limits of the evidence
The human data on selank next to another drug come from a comparative study with phenazepam in 60 patients, so they say little about selank compared with no treatment.[4]
More questions on Selank
More on Selank
Sources
- 1[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2008PMID 18454096Accessed 2 Oct 2026
- 2The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity.Bulletin of experimental biology and medicine · 2001PMID 11550013Accessed 2 Oct 2026
- 3[Optimization of the treatment of anxiety disorders with selank].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2015PMID 26356395Accessed 2 Oct 2026
- 4[A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2014PMID 25176261Accessed 2 Oct 2026
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