Does selank work?
In patients with generalized anxiety disorder and neurasthenia, selank and medazepam had similar anxiolytic effects.
Short answer
In patients with generalized anxiety disorder and neurasthenia, selank and medazepam had similar anxiolytic effects.[1]
In 60 patients with phobic-anxiety and somatoform disorders, pronounced anxiolytic and mild nootropic effects were reported, lasting a week after the last dose.[2]
How strong the evidence is
The human trials found compared selank with other drugs (medazepam, phenazepam), so they do not show how it compares with a placebo.[2]
Adding selank to phenazepam let the benzodiazepine's effect appear earlier on the Hamilton depression scale.[3]
In mice, an anxiolytic effect appeared only in the BALB/c strain, which has initially low exploratory activity, so animal results were not uniform.[4]
More questions on Selank
More on Selank
Sources
- 1[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2008PMID 18454096Accessed 2 Oct 2026
- 2[A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2014PMID 25176261Accessed 2 Oct 2026
- 3[Optimization of the treatment of anxiety disorders with selank].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2015PMID 26356395Accessed 2 Oct 2026
- 4[COMPARISON OF PHARMACOLOGICAL EFFECTS OF HEPTAPEPTIDE SELANK AFTER INTRANASAL AND INTRAPERITONEAL ADMINISTRATION TO BALB/c AND C57BL/6 MICE.].Eksperimental'naia i klinicheskaia farmakologiia · 2016PMID 29787664Accessed 2 Oct 2026
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