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Kisspeptin-10 vs Enclomiphene: What the Research Shows

Kisspeptin-10 and Enclomiphene side by side: what they are, how they are regulated and what is still unknown.

Medically reviewed by Juan Pablo Frías, MD · · DisclosureUpdated
GnRH stimulatorNot FDA approved · research chemicalKisspeptin-10GnRH-stimulating peptide, not FDA-approved; in healthy men, subcutaneous kisspeptin-10 infusions dose-dependently raised LH, FSH and testosterone versus vehicle.[5]Sexual & hormonal health+371% searchesSERM (not a peptide)Not FDA approved · compoundedEnclomipheneOral SERM (not a peptide), not FDA-approved; in men with secondary hypogonadism it raised morning serum testosterone to levels similar to those obtained with a topical testosterone gel.[16]Other+40% searches
Quick verdict

Where the research points

Summary of studies, not a recommendation

Consider Kisspeptin-10 if…

  • you want human hormone data (infusion in men; a hormone-level outcome): At 4 ug/kg/h for 22.5 h, LH rose from 5.4 to 20.8 IU/liter and testosterone from 16.6 to 24.0 nmol/liter.[17]
  • you want to see the dosing limitation in women: responses fell with repeated dosing: LH and FSH responses fell sharply by day 14 of twice-daily injections (LH +2.5 IU/liter, FSH +0.5 IU/liter).[18]

Consider Enclomiphene if…

  • you want an oral option with randomized testosterone data against a gel: At 25 mg daily, day-42 testosterone averaged 604 ng/dL versus 500 ng for transdermal testosterone.[9]
  • you want randomized data on sperm concentration versus testosterone gel: Sperm concentration stayed in the normal range with enclomiphene but fell markedly with testosterone gel.[8]

What they have in common

  • Kisspeptin is prohibited by WADA at all times, in and out of competition[1]
  • Enclomiphene is prohibited by WADA at all times, in and out of competition (a clomifene-type SERM)[1]
Both are prohibited in tested sport (WADA). Status labels come from public FDA and WADA records; see the sources below.
Side by side

Spec comparison

Showing 10 of 12 fields where the two differ. PCAC vote, Jul 2026, Evidence strength are the same or both unknown.

FieldKisspeptin-10Enclomiphene
ClassGnRH stimulatorSERM (not a peptide)
Also calledkissenclo
CategorySexual & hormonal healthOther
FDA statusNot FDA approved · research chemicalNot FDA approved · compounded
WADAProhibited by WADA (S2.2.1)Kisspeptin and its agonist analogues are named in S2.2.1 (testosterone-stimulating peptides in males).Prohibited by WADA (S4.2)Enclomiphene is an isomer of clomifene, which is named in S4.2 (anti-estrogens/SERMs, prohibited at all times). Enclomiphene itself is not spelled out in the list text we cached, so this rests on it being a form of clomifene.
Anti-doping detection
  • Kisspeptin-10 is cleared very fast (30 minutes in rats), so labs target metabolites.PMID 38978171
  • A 2026 method detects kisspeptins in serum and urine; samples from people who actually took them were not yet tested.PMID 42057309
  • In a study of men taking clomiphene (a mix of zuclomiphene and enclomiphene), the zuclomiphene isomer stayed detectable in urine for months. The abstract gives no window for enclomiphene itself.PMID 30295816
Half-lifemean elimination half-life 1.3-2.2 hourssubcutaneous (analog MVT-602) · Fertility and sterility 2024, PMID 37925096No published half-life foundPubMed search, 2 Oct 2026
Human studies we summarised13 human (10 randomized or controlled) of 16 summarised6 human (4 randomized or controlled) of 9 summarised
Typical study doses
US searches per month22,200 · +371% searches135,000 · +40% searches

Bracketed values are pending a sourced figure. Legal data reflects the regulatory events in our tracker.

Sources

  1. 1World Anti-Doping Code International Standard Prohibited List 2026World Anti-Doping Agency · 2026wada-ama.orgAccessed 2 Oct 2026
  2. 2[Not Available].Biomedical chromatography : BMC · 2024PMID 38978171Accessed 2 Oct 2026
  3. 3Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography-High-Resolution Mass Spectrometry for Doping Control Purposes.Drug testing and analysis · 2026PMID 42057309Accessed 2 Oct 2026
  4. 4Endocrine profile of the kisspeptin receptor agonist MVT-602 in healthy premenopausal women with and without ovarian stimulation: results from 2 randomized, placebo-controlled clinical tricals.Fertility and sterility · 2024PMID 37925096Accessed 2 Oct 2026
  5. 5Chronic subcutaneous kisspeptin-10 stimulates gonadotropin secretion for 12 days in healthy men.European journal of endocrinology · 2026PMID 42549827Accessed 2 Oct 2026
  6. 6Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial.JAMA network open · 2022PMID 36287566Accessed 2 Oct 2026
  7. 7Hypothalamic-Pituitary-Testicular Axis Effects and Urinary Detection Following Clomiphene Administration in Males.The Journal of clinical endocrinology and metabolism · 2019PMID 30295816Accessed 2 Oct 2026
  8. 8Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement.BJU international · 2016PMID 26496621Accessed 2 Oct 2026
  9. 9Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics.BJU international · 2013PMID 23875626Accessed 2 Oct 2026
  10. 10Newly Detected Atrial Flutter After Enclomiphene Dose Escalation in a Patient With Prior Mitral Valve Repair and Chronic Immune Thrombocytopenia: A Case Report.Cureus · 2026PMID 42741668Accessed 2 Oct 2026
  11. 11PubMed search: enclomiphene[tiab] OR enclomifene[tiab] OR "trans-clomiphene"[tiab] (98 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  12. 12PubMed search: (enclomiphene[tiab] OR enclomifene[tiab]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt]) (9 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  13. 13PubMed search: (enclomiphene[tiab] OR enclomifene[tiab]) AND (hypogonadism[tiab] OR testosterone[tiab]) AND humans[mh] (17 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  14. 14PubMed search: (enclomiphene[tiab] OR enclomifene[tiab]) AND (half-life[tiab] OR pharmacokinetic*[tiab]) (5 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  15. 15PubMed search: (enclomiphene[tiab] OR enclomifene[tiab] OR "trans-clomiphene"[tiab] OR Androxal[tiab]) AND ("kisspeptin-10"[tiab] OR "kisspeptin 10"[tiab])PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  16. 16Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone.Fertility and sterility · 2014PMID 25044085Accessed 2 Oct 2026
  17. 17Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men.The Journal of clinical endocrinology and metabolism · 2011PMID 21632807Accessed 2 Oct 2026
  18. 18Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis.The Journal of clinical endocrinology and metabolism · 2009PMID 19820030Accessed 2 Oct 2026

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