KLOW Half-Life: How Long It Stays in Your System
How long KLOW stays in the body, how that shapes dosing frequency, and what is known about drug testing.
- Half-life
- less than 30 min
- IV and IM (single and repeated), rat, beagle dog · Frontiers in pharmacology 2022, PMID 36588717
- Dosing interval
- Varies by study
- as used in studies
- WADA
- Prohibited (S0)
- In and out of competition
- Detection window
- 4 findings
- from anti-doping studies, below
KLOW half-life
A half-life depends on the route (under the skin, into a vein, by mouth or nasal spray) and the species it was measured in, so we report each value with its route and source. These are values for each ingredient of KLOW; none was measured for the blend.
| Route | Half-life | Measured in | Source |
|---|---|---|---|
| BPC-157: IV and IM (single and repeated) | less than 30 min | Animal · rat, beagle dog | Frontiers in pharmacology 2022, PMID 36588717 |
| BPC-157: not stated (review summary) | less than 30 minutes | Animal · review of preclinical data | HSS journal 2025, PMID 40756949 |
What half-life means
Half-life is the time it takes for the amount of a drug in the blood to fall by half. After one half-life, about 50% is left; after two, about 25%; after four to five, only a few percent remain.
- A long half-life lets a drug be dosed less often, for example once a week.
- A short half-life means levels rise and fall quickly, which is why some peptides are given daily or more often.
- Effects can outlast blood levels, so half-life alone does not tell you how long a drug works.
What it means for dosing frequency
Dosing intervals used in published studies of KLOW:
- TB-500: single dose or once daily, intravenous (Human RCT; Journal of cellular and molecular medicine 2021, PMID 34346165)
- TB-500: 6 times daily, eye drops (Human RCT; Cornea 2015, PMID 25826322)
- TB-500: single dose, then daily, intravenous (Human RCT; Annals of the New York Academy of Sciences 2010, PMID 20536472)
- BPC-157: once daily on 2 consecutive days, intravenous infusion over one hour (Human uncontrolled trial; Alternative therapies in health and medicine 2025, PMID 40131143)
Changing the interval changes how much drug builds up between doses, so it is not a free choice.
Drug tests and sport
Prohibited by WADA (S0)Contains BPC-157 (named in S0) and TB-500 (S2.3). A blend is prohibited if any component is.
Detection findings from anti-doping analytical studies:
- BPC-157: A 2023 method detects BPC-157 and five main metabolites in human urine at very low concentrations. · PMID 37959764
- BPC-157: A 2017 anti-doping lab method detects BPC 157 in urine; the peptide was stable in urine for at least 4 days. · PMID 28035768
- TB-500: A horse-racing doping method identified TB-500 and its metabolites in equine urine and plasma after a single dose (animal data, not human). · Journal of chromatography. A 2012, PMID 23084823
- TB-500: A direct-urine screen includes TB-500 among the peptides it can detect, at 50 to 500 pg/mL. · PMID 26578461
Tested athletes should treat it as prohibited (s0) at all times.
The one measured half-life among the four components
In rats and beagle dogs, the elimination half-life of the unchanged BPC157 peptide was under half an hour.[2]
The review of BPC-157 in sports medicine repeats that figure and adds how the peptide is cleared.[3]
PubMed counts from 2 Oct 2026 of records matching half-life or pharmacokinetic words are 7 for BPC-157, 2 for GHK-Cu, 16 for TB-500 or thymosin beta-4 and 2 for KPV, and the figures belong to single peptides, not to the four-peptide vial.
Calculated from date 2026-10-02; bpc157 7; ghk cu 2; tb500 or thymosin beta4 16; kpv 2; source web/src/data/evidence/*.json searches. Formula: counts reported as recorded; no half-life derived
Common questions
How long does KLOW stay in your system?
Its reported half-life is less than 30 min (IV and IM (single and repeated), rat, beagle dog); less than 30 minutes (not stated (review summary), review of preclinical data). Most of a dose is gone after about four to five half-lives.
What is the half-life of KLOW?
No half-life exists for the blend; the one cached component value is under 30 minutes for BPC157 in animals.[2]
Is KLOW on the WADA prohibited list?
Yes. Prohibited by WADA (S0).
More on KLOW
Sources
- 1World Anti-Doping Code International Standard Prohibited List 2026World Anti-Doping Agency · 2026wada-ama.orgAccessed 2 Oct 2026
- 2Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157, a potential drug for treating various wounds, in rats and dogs.Frontiers in pharmacology · 2022PMID 36588717Accessed 2 Oct 2026
- 3Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2025PMID 40756949Accessed 2 Oct 2026
- 4A first-in-human, randomized, double-blind, single- and multiple-dose, phase I study of recombinant human thymosin β4 in healthy Chinese volunteers.Journal of cellular and molecular medicine · 2021PMID 34346165Accessed 2 Oct 2026
- 5Thymosin β4 significantly improves signs and symptoms of severe dry eye in a phase 2 randomized trial.Cornea · 2015PMID 25826322Accessed 2 Oct 2026
- 6A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin beta4 in healthy volunteers.Annals of the New York Academy of Sciences · 2010PMID 20536472Accessed 2 Oct 2026
- 7Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study.Alternative therapies in health and medicine · 2025PMID 40131143Accessed 2 Oct 2026
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