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Melanotan II Dosage: Doses Studied, Units and Chart

What doses of Melanotan II have been used in published research, how they convert to syringe units, and what is still unknown.

Medically reviewed by Juan Pablo Frías, MD · · DisclosureMelanocortin agonistUpdated
Doses studied
5 studies
with a stated dose, listed below
Frequency
Varies by study
as used in studies
Half-life
Not found
No published half-life found (PubMed search, 2 Oct 2026)
Vial sizes sold
10 mg

Doses used in published studies

Each dose below is quoted from a study abstract, strongest design first. Animal doses are labelled and do not translate directly to people. None of them is a recommendation.

Doses of Melanotan II used in published studies
DoseFrequency and routeStudy typeSource
0.025 mg/kg (dose with severe nausea reported)Not stated in the abstractHuman controlled trialn = 20International journal of impotence research 2000, PMID 11035391
0.01 mg/kg start, escalated to 0.025-0.03 mg/kgdaily Monday to Friday · subcutaneous · 2 consecutive weeksHuman controlled trialn = 3Life sciences 1996, PMID 8637402
6 mgsubcutaneousHuman case reportn = 1Clinical toxicology 2012, PMID 23121206
1 and 3 mg/kg10 min before each paced mating test · intravenousAnimal · rat (not a human result)n = 14Pharmacology, biochemistry, and behavior 2006, PMID 17113634
15 nmol/dayintracerebroventricular infusion · 7 daysAnimal · rat (not a human result)Journal of neuroendocrinology 2003, PMID 12535159

Dose to syringe units

For a 10 mg vial mixed with 2 mL of bacteriostatic water (5 mg/mL), on a U-100 syringe. These are reference amounts for the math, not suggested doses.

100 mcg
2 u
250 mcg
5 u
500 mcg
10 u
750 mcg
15 u
1000 mcg
20 u
Use your own vial and water

Before anyone considers it

  • Melanotan II is not FDA approved for any use.
  • Products sold as research chemicals are not checked by the FDA for identity, purity or dose.
  • Reconstitution math (mg vs mcg, units vs mL) is the most asked question in peptide forums. Check every number twice.
  • People who are pregnant, breastfeeding, or have a chronic condition need medical advice first.

Common questions

How many units is 500 mcg of Melanotan II?

It depends on the water added. A 10 mg vial with 2 mL of water gives 5 mg/mL, so 500 mcg is 10 units on a U-100 syringe. Use the calculator for other mixes.

Is Melanotan II FDA approved?

No. Melanotan II is not FDA approved for any use. The FDA removed it from Category 2 on 15 Apr 2026.

More on Melanotan II

Side effectsWhat labels and studies report, and what is unknown.CalculatorVial, water and dose to syringe units.ResultsStudy outcomes and when they were measured.PricePrice per mg and per week from dated listings. No vendor links.Legal statusFDA, compounding and WADA status with dates.How to injectSites, syringe types and hygiene, step by step.

Sources

  1. 1Certain bulk drug substances for use in compounding that may present significant safety risks (Category 2; 'nominated but withdrawn' table, content current as of 22 Apr 2026)U.S. Food and Drug Administration · 2026fda.govAccessed 2 Oct 2026
  2. 2Metric (SI) Prefixes (NIST Reference on Constants, Units, and Uncertainty)National Institute of Standards and Technology (NIST) · 2025physics.nist.govAccessed 2 Oct 2026
  3. 3BASAGLAR (insulin glargine) injection, prescribing information (DailyMed)U.S. Food and Drug Administration / DailyMed (Eli Lilly and Company label) · 2026dailymed.nlm.nih.govAccessed 2 Oct 2026
  4. 4Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II.International journal of impotence research · 2000PMID 11035391Accessed 2 Oct 2026
  5. 5Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.Life sciences · 1996PMID 8637402Accessed 2 Oct 2026
  6. 6Melanotan II injection resulting in systemic toxicity and rhabdomyolysis.Clinical toxicology (Philadelphia, Pa.) · 2012PMID 23121206Accessed 2 Oct 2026
  7. 7The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in the female rat.Pharmacology, biochemistry, and behavior · 2006PMID 17113634Accessed 2 Oct 2026
  8. 8The melanocortin agonist Melanotan-II reduces the orexigenic and adipogenic effects of neuropeptide Y (NPY) but does not affect the NPY-driven suppressive effects on the gonadotropic and somatotropic axes in the male rat.Journal of neuroendocrinology · 2003PMID 12535159Accessed 2 Oct 2026
  9. 9PubMed search: "melanotan II"[tiab] OR "melanotan 2"[tiab] (198 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  10. 10PubMed search: ("melanotan II"[tiab] OR melanotan[tiab]) AND humans[mh] (82 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  11. 11PubMed search: ("melanotan II"[tiab] OR "melanotan 2"[tiab] OR melanotan[ti]) AND (case[tiab] OR naevi[tiab] OR nevi[tiab] OR melanoma[tiab] OR adverse[tiab] OR priapism[tiab] OR tanning[tiab] OR sunless[tiab]) AND humans[mh] (25 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  12. 12PubMed search: ("melanotan II"[tiab] OR "melanotan 2"[tiab]) AND (half-life[tiab] OR pharmacokinetic*[tiab]) (3 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026

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