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Melanotan II

Melanocortin agonist. Melanotan II is not FDA approved for any use.

Also called:MT2MT-II
Medically reviewed by Juan Pablo Frías, MD · · DisclosureUpdated Strongest evidence: Human RCT evidence, 4 of 4
StatusOff FDA Category 2 (Apr 2026)Removed from FDA Category 2 on 15 Apr 2026. WADA status unclearFull legal history

Key facts

How we verify
Class
Melanocortin agonist
Also called
MT2, MT-II
Vial sizes sold
10 mg
Community-reported sizes
Half-life
Not found
No published half-life found (PubMed search, 2 Oct 2026)
FDA status
Not approved
Off Category 2, 15 Apr 2026
PCAC vote
Not reviewed
not on the Jul 2026 PCAC agenda
WADA
Unclear
Not named on the 2026 list
Everything on Melanotan II

Melanotan II guides

DosageDoses used in published studies, with the source for each.Side effectsWhat labels and studies report, and what is unknown.CalculatorVial, water and dose to syringe units.ResultsStudy outcomes and when they were measured.PricePrice per mg and per week from dated listings. No vendor links.Legal statusFDA, compounding and WADA status with dates.How to injectSites, syringe types and hygiene, step by step.Half-lifeWhat is measured, by route, and what is not.StoragePowder and mixed vials: temperature and shelf life.10 mg vialConcentration and unit tables for the 10 mg size.

Evidence at a glance

Human and animal counts are PubMed records from our evidence ledger (search counts, not studies we reviewed). The grade is the strongest design among the studies we summarised for that goal: a human randomized trial outweighs any number of animal studies.

Melanotan II: studies by condition
ConditionHuman studiesAnimal studiesStudies we summarisedEvidence grade
Tanning933Human RCT evidence, 4 of 4Life sciences 1996, PMID 8637402

Grades follow our evidence scale. Summarised studies come from our evidence file, each quote checked against the abstract or label.

Common stacks

Melanotan II is often sold pre-mixed or combined with other peptides. No controlled study has tested these combinations; the pages below cover the math and what each part has been studied for.

Melanotan II + GHK-Cu

Common questions

Is Melanotan II FDA approved?

No. Melanotan II is not FDA approved for any use. The FDA removed it from Category 2 on 15 Apr 2026.

How much water goes in a 10 mg vial?

That choice only changes the concentration. With 2 mL, the vial is 5 mg/mL. The calculator converts any amount to syringe units. It does the math only and does not suggest a dose.

Sources

  1. 1Certain bulk drug substances for use in compounding that may present significant safety risks (Category 2; 'nominated but withdrawn' table, content current as of 22 Apr 2026)U.S. Food and Drug Administration · 2026fda.govAccessed 2 Oct 2026
  2. 2US search volume and year-over-year trend, Google Keyword Planner export (Jun–Aug 2026 vs 2025)Peptigraph research · 2026peptigraph.com/methodology/Accessed 1 Oct 2026
  3. 3World Anti-Doping Code International Standard Prohibited List 2026World Anti-Doping Agency · 2026wada-ama.orgAccessed 2 Oct 2026
  4. 4United States: No FDA-approved product found: Drugs@FDA (openFDA) search for active ingredient "Melanotan II" returned no matches on 2 Oct 2026.U.S. Food and Drug Administration · 2026api.fda.govAccessed 2 Oct 2026
  5. 5US compounding: Melanotan II was removed from FDA's 503A category 2 after the nominators withdrew; FDA announced a PCAC consultation before the end of February 2027.U.S. Food and Drug Administration · 2026fda.govAccessed 2 Oct 2026
  6. 6Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.Life sciences · 1996PMID 8637402Accessed 2 Oct 2026
  7. 7Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II.International journal of impotence research · 2000PMID 11035391Accessed 2 Oct 2026
  8. 8PubMed search: "melanotan II"[tiab] OR "melanotan 2"[tiab] (198 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  9. 9PubMed search: ("melanotan II"[tiab] OR melanotan[tiab]) AND humans[mh] (82 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  10. 10PubMed search: ("melanotan II"[tiab] OR "melanotan 2"[tiab] OR melanotan[ti]) AND (case[tiab] OR naevi[tiab] OR nevi[tiab] OR melanoma[tiab] OR adverse[tiab] OR priapism[tiab] OR tanning[tiab] OR sunless[tiab]) AND humans[mh] (25 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  11. 11PubMed search: ("melanotan II"[tiab] OR "melanotan 2"[tiab]) AND (half-life[tiab] OR pharmacokinetic*[tiab]) (3 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  12. 12FDA gives notice that 12 peptides will be removed from Category 2 (nominations withdrawn)FDA · 2026fda.govAccessed 2 Oct 2026

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