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BPC-157 and Wolverine Together: What Is Known

BPC-157 and Wolverine taken together: what each one is, how each is regulated, and what is known about combining them.

Medically reviewed by Juan Pablo Frías, MD · · DisclosureUpdated
Gastric pentadecapeptidePCAC voted 8–6 for 503A (Jul 2026)BPC-157BPC-157, an experimental gastric pentadecapeptide, not an approved drug; human evidence is a few small uncontrolled reports, including complete symptom resolution in 10 of 12 patients in a bladder pilot.[7]Healing & recoveryBPC-157 + TB-500 blendNot FDA approved · unstudied blendWolverineUnapproved blend of BPC-157 and TB-500; an FDA Drugs@FDA search for its component BPC-157 returned no matches, so no approved product was found.[16]Healing & recovery
Interaction notes

Timing, interactions and safety

Evidence for the combination

  • Rat Achilles tendon study of BPC-157, TB-500 and their combination (the components of the Wolverine blend). The combination gave no added benefit over either agent alone. Animal data only. · PMID 42542926
BPC-157 is not FDA approved. The studies above describe research settings, not a recommendation to combine them. Ask the prescriber who manages both.
Each component

Side by side

Showing 10 of 13 fields where the two differ. Category, WADA, Half-life are the same or both unknown.

FieldBPC-157Wolverine
ClassGastric pentadecapeptideBPC-157 + TB-500 blend
Also calledBPC, body protection compound, Pentadecapeptide BPC 157Wolverine stack, BPC-157 + TB-500
FDA statusPCAC voted 8–6 for 503A (Jul 2026)Not FDA approved · unstudied blend
PCAC vote, Jul 2026PCAC voted 8–6 for the 503A list (Jul 2026); not finalizedNot on the Jul 2026 agenda
Anti-doping detection
  • A 2023 method detects BPC-157 and five main metabolites in human urine at very low concentrations.PMID 37959764
  • A 2017 anti-doping lab method detects BPC 157 in urine; the peptide was stable in urine for at least 4 days.PMID 28035768
  • BPC-157: A 2023 method detects BPC-157 and five main metabolites in human urine at very low concentrations.PMID 37959764
  • BPC-157: A 2017 anti-doping lab method detects BPC 157 in urine; the peptide was stable in urine for at least 4 days.PMID 28035768
  • TB-500: A horse-racing doping method identified TB-500 and its metabolites in equine urine and plasma after a single dose (animal data, not human).Journal of chromatography. A 2012, PMID 23084823
  • TB-500: A direct-urine screen includes TB-500 among the peptides it can detect, at 50 to 500 pg/mL.PMID 26578461
Evidence strengthHuman observational evidence, 3 of 4Strongest: Alternative therapies in health and medicine 2025, PMID 40131143Human RCT evidence, 4 of 4TB-500: Cardiovascular research 2025, PMID 41229390
Human studies we summarised3 human (0 randomized or controlled) of 24 summarised10 human (7 randomized or controlled) of 40 summarised, across ingredients
Typical study doses
Vial sizes sold2 mg, 5 mg, 10 mg, 20 mg10 mg, 20 mg
US searches per month301,000 · Most searched27,100 · +440% searches

What people search

  • bpc157 wolverine stack480/mo
  • wolverine stack bpc 157170/mo
  • bpc 157 wolverine stack dosage30/mo

US monthly searches, Google Keyword Planner, Oct 2026. Shown so you can see which questions this page answers.

Sources

  1. 1FDA gives notice that 12 peptides will be removed from Category 2 (nominations withdrawn)FDA · 2026fda.govAccessed 2 Oct 2026
  2. 2World Anti-Doping Code International Standard Prohibited List 2026World Anti-Doping Agency · 2026wada-ama.orgAccessed 2 Oct 2026
  3. 3Stable Isotope Labeling-Based Nontargeted Strategy for Characterization of the In Vitro Metabolic Profile of a Novel Doping BPC-157 in Doping Control by UHPLC-HRMS.Molecules (Basel, Switzerland) · 2023PMID 37959764Accessed 2 Oct 2026
  4. 4Detection and in vitro metabolism of the confiscated peptides BPC 157 and MGF R23H.Drug testing and analysis · 2017PMID 28035768Accessed 2 Oct 2026
  5. 5Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157, a potential drug for treating various wounds, in rats and dogs.Frontiers in pharmacology · 2022PMID 36588717Accessed 2 Oct 2026
  6. 6Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study.Alternative therapies in health and medicine · 2025PMID 40131143Accessed 2 Oct 2026
  7. 7Effect of BPC-157 on Symptoms in Patients with Interstitial Cystitis: A Pilot Study.Alternative therapies in health and medicine · 2024PMID 39325560Accessed 2 Oct 2026
  8. 8Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study.Joint diseases and related surgery · 2026PMID 42542926Accessed 2 Oct 2026
  9. 9Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometry.Journal of chromatography. A · 2012PMID 23084823Accessed 2 Oct 2026
  10. 10Simplifying and expanding the screening for peptides <2 kDa by direct urine injection, liquid chromatography, and ion mobility mass spectrometry.Journal of separation science · 2016PMID 26578461Accessed 2 Oct 2026
  11. 11Recombinant human thymosin beta 4 improves ischemic cardiac dysfunction in mice and patients with acute ST-segment elevation myocardial infarction after reperfusion.Cardiovascular research · 2025PMID 41229390Accessed 2 Oct 2026
  12. 12A first-in-human, randomized, double-blind, single- and multiple-dose, phase I study of recombinant human thymosin β4 in healthy Chinese volunteers.Journal of cellular and molecular medicine · 2021PMID 34346165Accessed 2 Oct 2026
  13. 13Recombinant human thymosin beta-4 (rhTβ4) improved scalp condition and microbiome homeostasis in seborrheic dermatitis.Microbial biotechnology · 2021PMID 34318587Accessed 2 Oct 2026
  14. 14Thymosin β4 significantly improves signs and symptoms of severe dry eye in a phase 2 randomized trial.Cornea · 2015PMID 25826322Accessed 2 Oct 2026
  15. 15PubMed search: ("BPC-157"[tiab] OR BPC157[tiab] OR "body protection compound"[tiab] OR "pentadecapeptide BPC"[tiab]) AND (("BPC-157"[tiab] OR BPC157[tiab] OR "body protection compound"[tiab] OR "pentadecapeptide BPC"[tiab]) AND ("TB-500"[tiab] OR TB500[tiab] OR "thymosin beta-4"[tiab] OR "thymosin beta4"[tiab] OR Tbeta4[tiab]))PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  16. 16Drugs@FDA (openFDA) search: active ingredient "BPC-157"U.S. Food and Drug Administration · 2026api.fda.govAccessed 2 Oct 2026
  17. 17Advisory committee backs 6 of 7 peptides for the 503A listNCPA · 2026ncpa.org

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