Skip to content
Peptigraph home

Enclomiphene and Sermorelin Together: What Is Known

Enclomiphene and Sermorelin taken together: what each one is, how each is regulated, and what is known about combining them.

Medically reviewed by Juan Pablo Frías, MD · · DisclosureUpdated
SERM (not a peptide)Not FDA approved · compoundedEnclomipheneOral SERM (not a peptide), not FDA-approved; in men with secondary hypogonadism it raised morning serum testosterone to levels similar to those obtained with a topical testosterone gel.[19]OtherGHRH analogCompounded by prescriptionSermorelinGHRH analog once FDA-approved as Geref and since discontinued; in an uncontrolled pediatric study mean height velocity rose from 4.1 to 8.0 cm/yr after 6 months.[20]Growth hormone
Interaction notes

Timing, interactions and safety

Evidence for the combination

No studies tested these together (PubMed search: 0 results, 2 Oct 2026).

Sermorelin is not FDA approved, and we have no sourced data on combining it with Enclomiphene.
Each component

Side by side

Showing 9 of 12 fields where the two differ. PCAC vote, Jul 2026, Half-life, Evidence strength are the same or both unknown.

FieldEnclomipheneSermorelin
ClassSERM (not a peptide)GHRH analog
Also calledenclo—
CategoryOtherGrowth hormone
FDA statusNot FDA approved · compoundedCompounded by prescription
WADAProhibited by WADA (S4.2)Enclomiphene is an isomer of clomifene, which is named in S4.2 (anti-estrogens/SERMs, prohibited at all times). Enclomiphene itself is not spelled out in the list text we cached, so this rests on it being a form of clomifene.Prohibited by WADA (S2.2.4)Sermorelin is named as a GHRH analogue in S2.2.4 (growth hormone releasing factors), prohibited at all times.
Anti-doping detection
  • In a study of men taking clomiphene (a mix of zuclomiphene and enclomiphene), the zuclomiphene isomer stayed detectable in urine for months. The abstract gives no window for enclomiphene itself.PMID 30295816
  • A urine assay detects CJC-1295 and other GHRH analogues at very low concentrations.PMID 35298973
  • Labs expect GHRH analogues like CJC-1295 to be hard to find because of tiny urine concentrations; the study reports no detections in routine anti-doping samples.PMID 34665524
Human studies we summarised6 human (4 randomized or controlled) of 9 summarised4 human (1 randomized or controlled) of 7 summarised
Typical study doses
US searches per month135,000 · +40% searches165,000 · Flat YoY
Related tools

Enclomiphene vs Sermorelin

Choosing between the two rather than combining them? The comparison lines them up field by field.

Open the comparison
ComparisonEnclomiphene vs Sermorelin

What people search

  • enclomiphene and sermorelin90/mo
  • sermorelin and enclomiphene together70/mo
  • sermorelin and enclomiphene70/mo
  • enclomiphene and sermorelin together50/mo
  • sermorelin with enclomiphene30/mo
  • enclomiphene with sermorelin30/mo

US monthly searches, Google Keyword Planner, Oct 2026. Shown so you can see which questions this page answers.

Sources

  1. 1World Anti-Doping Code International Standard Prohibited List 2026World Anti-Doping Agency · 2026wada-ama.orgAccessed 2 Oct 2026
  2. 2Hypothalamic-Pituitary-Testicular Axis Effects and Urinary Detection Following Clomiphene Administration in Males.The Journal of clinical endocrinology and metabolism · 2019PMID 30295816Accessed 2 Oct 2026
  3. 3Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement.BJU international · 2016PMID 26496621Accessed 2 Oct 2026
  4. 4Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics.BJU international · 2013PMID 23875626Accessed 2 Oct 2026
  5. 5Newly Detected Atrial Flutter After Enclomiphene Dose Escalation in a Patient With Prior Mitral Valve Repair and Chronic Immune Thrombocytopenia: A Case Report.Cureus · 2026PMID 42741668Accessed 2 Oct 2026
  6. 6PubMed search: enclomiphene[tiab] OR enclomifene[tiab] OR "trans-clomiphene"[tiab] (98 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  7. 7PubMed search: (enclomiphene[tiab] OR enclomifene[tiab]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt]) (9 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  8. 8PubMed search: (enclomiphene[tiab] OR enclomifene[tiab]) AND (hypogonadism[tiab] OR testosterone[tiab]) AND humans[mh] (17 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  9. 9PubMed search: (enclomiphene[tiab] OR enclomifene[tiab]) AND (half-life[tiab] OR pharmacokinetic*[tiab]) (5 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  10. 10An antibody-free, ultrafiltration-based assay for the detection of growth hormone-releasing hormones in urine at low pg/mL concentrations using nanoLC-HRMS/MS.Journal of pharmaceutical and biomedical analysis · 2022PMID 35298973Accessed 2 Oct 2026
  11. 11Advances in the detection of growth hormone releasing hormone synthetic analogs.Drug testing and analysis · 2021PMID 34665524Accessed 2 Oct 2026
  12. 12Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men.The Journal of clinical endocrinology and metabolism · 1992PMID 1379256Accessed 2 Oct 2026
  13. 13Growth Hormone Secretagogue Treatment in Hypogonadal Men Raises Serum Insulin-Like Growth Factor-1 Levels.American journal of men's health · 2017PMID 28830317Accessed 2 Oct 2026
  14. 14Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men.Metabolism: clinical and experimental · 1997PMID 9005976Accessed 2 Oct 2026
  15. 15PubMed search: (sermorelin[tiab] OR Geref[tiab]) (34 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  16. 16PubMed search: (sermorelin[tiab] OR "GHRH(1-29)"[tiab] OR "GRF(1-29)"[tiab] OR "GHRH 1-29"[tiab]) AND (elderly[tiab] OR aging[tiab] OR "older adults"[tiab] OR adults[tiab]) AND (treatment[tiab] OR therapy[tiab] OR administration[tiab]) (15 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  17. 17PubMed search: (sermorelin[tiab] OR Geref[tiab]) AND (half-life[tiab] OR pharmacokinetic*[tiab]) (2 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  18. 18PubMed search: (enclomiphene[tiab] OR enclomifene[tiab] OR "trans-clomiphene"[tiab] OR Androxal[tiab]) AND (sermorelin[tiab] OR Geref[tiab])PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  19. 19Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone.Fertility and sterility · 2014PMID 25044085Accessed 2 Oct 2026
  20. 20Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy. Geref International Study Group.The Journal of clinical endocrinology and metabolism · 1996PMID 8772599Accessed 2 Oct 2026

Found an error? Report a correction.