Sermorelin
GHRH analog. Sermorelin is not FDA approved for any use.
Medically reviewed by Juan Pablo Frías, MD · · DisclosureUpdated Strongest evidence: Human RCT evidence, 4 of 4
Key facts
How we verify- Class
- GHRH analog
- Also called
- No common aliases
- Vial sizes sold
- 2 mg, 5 mg, 9 mg, 15 mg
- Community-reported sizes
- Half-life
- Not found
- No published half-life found (PubMed search, 2 Oct 2026)
- FDA status
- Compounded by prescription
- Discontinued
- WADA
- Prohibited (S2.2.4)
- In and out of competition
Everything on Sermorelin
Sermorelin guides
01DosageDoses used in published studies, with the source for each.02Side effectsWhat labels and studies report, and what is unknown.03CalculatorVial, water and dose to syringe units.04ResultsStudy outcomes and when they were measured.05PricePrice per mg and per week from dated listings. No vendor links.06Legal statusFDA, compounding and WADA status with dates.07How to injectSites, syringe types and hygiene, step by step.08Half-lifeWhat is measured, by route, and what is not.09StoragePowder and mixed vials: temperature and shelf life.1010 mg doseHow many units 10 mg is at common concentrations.11For weight lossWhat research says about Sermorelin for weight loss.12For muscle growthWhat research says about Sermorelin for muscle growth.13For menopauseWhat research says about Sermorelin for menopause.
Vial and dose sizes
Researched for
Evidence at a glance
Human and animal counts are PubMed records from our evidence ledger (search counts, not studies we reviewed). The grade is the strongest design among the studies we summarised for that goal: a human randomized trial outweighs any number of animal studies.
| Condition | Human studies | Animal studies | Studies we summarised | Evidence grade |
|---|---|---|---|---|
| Weight loss | 4 | 0 | 1 | Human observational evidence, 3 of 4Metabolism: clinical and experimental 1997, PMID 9005976 |
| Muscle growth | 2 | 0 | 3 | Human observational evidence, 3 of 4American journal of men's health 2017, PMID 28830317 |
| Menopause | 0 | 0 | 0 | No graded study for this goal |
| Testosterone | 2 | 0 | 1 | Human observational evidence, 3 of 4American journal of men's health 2017, PMID 28830317 |
| Sleep | 2 | 0 | 0 | No graded study for this goal |
| Hair | 0 | 0 | 0 | No graded study for this goal |
| Energy | 0 | 0 | 0 | No graded study for this goal |
Grades follow our evidence scale. Summarised studies come from our evidence file, each quote checked against the abstract or label.
Compared with
SermorelinvsTesamorelinGHRH analog next to ghrh analog: evidence, dosing and legal status side by side.FDA approved (Egrifta)Read the comparison →SermorelinvsIpamorelinGHRH analog next to ghrp (ghrelin receptor agonist): evidence, dosing and legal status side by side.Not FDA approved · research chemicalRead the comparison →SermorelinvsCJC-1295GHRH analog next to ghrh analog: evidence, dosing and legal status side by side.Not FDA approved · research chemicalRead the comparison →SermorelinvsCJC-1295 + IpamorelinGHRH analog next to ghrh + ghrp blend: evidence, dosing and legal status side by side.Not FDA approved · research blendRead the comparison →
Common stacks
Sermorelin is often sold pre-mixed or combined with other peptides. No controlled study has tested these combinations; the pages below cover the math and what each part has been studied for.
Common questions
Is Sermorelin FDA approved?
No. Sermorelin is not FDA approved for any use.
Is Sermorelin banned in sport?
Yes. Prohibited by WADA (S2.2.4), so it is prohibited at all times for tested athletes.
How much water goes in a 5 mg vial?
That choice only changes the concentration. With 2 mL, the vial is 2.5 mg/mL. The calculator converts any amount to syringe units. It does the math only and does not suggest a dose.
Sources
- 1US search volume and year-over-year trend, Google Keyword Planner export (Jun–Aug 2026 vs 2025)Peptigraph research · 2026peptigraph.com/methodology/Accessed 1 Oct 2026
- 2World Anti-Doping Code International Standard Prohibited List 2026World Anti-Doping Agency · 2026wada-ama.orgAccessed 2 Oct 2026
- 3United States: The only Drugs@FDA record for sermorelin is Geref (EMD Serono), with marketing status Discontinued; no currently marketed FDA-approved sermorelin product was found on 2 Oct 2026.U.S. Food and Drug Administration · 2026api.fda.govAccessed 2 Oct 2026
- 4Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men.Metabolism: clinical and experimental · 1997PMID 9005976Accessed 2 Oct 2026
- 5Growth Hormone Secretagogue Treatment in Hypogonadal Men Raises Serum Insulin-Like Growth Factor-1 Levels.American journal of men's health · 2017PMID 28830317Accessed 2 Oct 2026
- 6Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men.The Journal of clinical endocrinology and metabolism · 1992PMID 1379256Accessed 2 Oct 2026
- 7PubMed search: (sermorelin[tiab] OR Geref[tiab]) (34 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
- 8PubMed search: (sermorelin[tiab] OR "GHRH(1-29)"[tiab] OR "GRF(1-29)"[tiab] OR "GHRH 1-29"[tiab]) AND (elderly[tiab] OR aging[tiab] OR "older adults"[tiab] OR adults[tiab]) AND (treatment[tiab] OR therapy[tiab] OR administration[tiab]) (15 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
- 9PubMed search: (sermorelin[tiab] OR Geref[tiab]) AND (half-life[tiab] OR pharmacokinetic*[tiab]) (2 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
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