Sermorelin Side Effects: What Studies and Users Report

What FDA labels and clinical studies report for Sermorelin, how strong that evidence is, and what is still unknown.

Medically reviewed by Juan Pablo Frías, MD · 3 Oct 2026 · DisclosureGHRH analogUpdated 3 Oct 2026

Side effects reported in studies

Side effects reported in published studies, strongest design first. Frequencies are quoted as the source gives them; animal results are labelled.

Side effects of Sermorelin in labels and published studies
Side effect	How common	Study type	Source
Safety labs“GHRH treatment did not affect fasting glucose, urinary C-peptide, blood pressure, or chemistry and hematology profiles.”	Frequency not stated	Human RCTn = 10	The Journal of clinical endocrinology and metabolism 1992, PMID 1379256
Adverse effects“No significant adverse effects were observed.”	Frequency not stated	Human uncontrolled trialn = 11	Metabolism: clinical and experimental 1997, PMID 9005976
Safety“No adverse changes in general biochemical or hormonal analyses were noted. No change in fasting glucose concentration or excessive generation of insulin-like growth factor I occurred, and overall GHRH was well tolerated.”	Frequency not stated	Human uncontrolled trialn = 110	The Journal of clinical endocrinology and metabolism 1996, PMID 8772599
Flushing and injection-site pain	most commonly reported	Review	BioDrugs 1999, PMID 18031173

What is not known

How common each effect is at the doses people use outside of studies.
Effects that take longer to appear than the length of the published studies.
How Sermorelin interacts with other medicines and supplements.
Whether research-grade products, which are not checked by the FDA, behave like the material used in studies.

When to get medical help

Get urgent care for: trouble breathing, swelling of the face or throat, a widespread rash, severe or lasting stomach pain, fainting, or an injection site that becomes hot, red and spreading.

This is not a complete list. A doctor or pharmacist can help you judge whether a symptom is related.

Common questions

What are the side effects of Sermorelin?

Studies we summarise reported safety labs, adverse effects, safety. The table on this page gives how often each happened and links each source.

Is Sermorelin safe?

Its safety has not been established by an FDA review. Sermorelin is not FDA approved for any use. Research-chemical products are not checked for purity or dose.

Is Sermorelin banned in sport?

Yes. Prohibited by WADA (S2.2.4). Tested athletes should not use it.

More on Sermorelin

DosageDoses used in published studies, with the source for each.CalculatorVial, water and dose to syringe units.ResultsStudy outcomes and when they were measured.PricePrice per mg and per week from dated listings. No vendor links.Legal statusFDA, compounding and WADA status with dates.How to injectSites, syringe types and hygiene, step by step.

Sources

1Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men.The Journal of clinical endocrinology and metabolism · 1992PMID 1379256Accessed 2 Oct 2026
2Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men.Metabolism: clinical and experimental · 1997PMID 9005976Accessed 2 Oct 2026
3Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy. Geref International Study Group.The Journal of clinical endocrinology and metabolism · 1996PMID 8772599Accessed 2 Oct 2026
4Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 1999PMID 18031173Accessed 2 Oct 2026

Found an error? Report a correction.