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Sermorelin Dosage: Doses Studied, Units and Chart

What doses of Sermorelin have been used in published research, how they convert to syringe units, and what is still unknown.

Medically reviewed by Juan Pablo Frías, MD · · DisclosureGHRH analogUpdated
Doses studied
5 studies
with a stated dose, listed below
Frequency
Varies by study
as used in studies
Half-life
Not found
No published half-life found (PubMed search, 2 Oct 2026)
Vial sizes sold
2 mg, 5 mg, 9 mg, 15 mg

Doses used in published studies

Each dose below is quoted from a study abstract, strongest design first. Animal doses are labelled and do not translate directly to people. None of them is a recommendation.

Doses of Sermorelin used in published studies
DoseFrequency and routeStudy typeSource
0.5 mg (low) and 1 mg (high) GHRH-(1-29)twice daily · subcutaneous · 14 days per dose, with a 14-day washoutHuman RCTn = 10The Journal of clinical endocrinology and metabolism 1992, PMID 1379256
100 mcg each of GHRP-6, GHRP-2 and sermorelinthree times daily · not stated · mean 134 daysHuman observationaln = 14American journal of men's health 2017, PMID 28830317
2 mg GHRH (1-29)nightly self-injection · subcutaneous · 6 weeksHuman uncontrolled trialn = 11Metabolism: clinical and experimental 1997, PMID 9005976
30 micrograms/kg/day GHRH-(1-29)once daily at bedtime · subcutaneous · up to 1 yrHuman uncontrolled trialn = 110The Journal of clinical endocrinology and metabolism 1996, PMID 8772599
30 microg/kg bodyweightonce daily at bedtime · subcutaneousReviewBioDrugs 1999, PMID 18031173

Dose to syringe units

For a 5 mg vial mixed with 2 mL of bacteriostatic water (2.5 mg/mL), on a U-100 syringe. These are reference amounts for the math, not suggested doses.

100 mcg
4 u
200 mcg
8 u
300 mcg
12 u
400 mcg
16 u
500 mcg
20 u
750 mcg
30 u
Use your own vial and water

Before anyone considers it

  • Sermorelin is not FDA approved for any use.
  • Products sold as research chemicals are not checked by the FDA for identity, purity or dose.
  • Reconstitution math (mg vs mcg, units vs mL) is the most asked question in peptide forums. Check every number twice.
  • People who are pregnant, breastfeeding, or have a chronic condition need medical advice first.

Common questions

How many units is 300 mcg of Sermorelin?

It depends on the water added. A 5 mg vial with 2 mL of water gives 2.5 mg/mL, so 300 mcg is 12 units on a U-100 syringe. Use the calculator for other mixes.

Is Sermorelin FDA approved?

No. Sermorelin is not FDA approved for any use.

More on Sermorelin

Side effectsWhat labels and studies report, and what is unknown.CalculatorVial, water and dose to syringe units.ResultsStudy outcomes and when they were measured.PricePrice per mg and per week from dated listings. No vendor links.Legal statusFDA, compounding and WADA status with dates.How to injectSites, syringe types and hygiene, step by step.

Sources

  1. 1Metric (SI) Prefixes (NIST Reference on Constants, Units, and Uncertainty)National Institute of Standards and Technology (NIST) · 2025physics.nist.govAccessed 2 Oct 2026
  2. 2BASAGLAR (insulin glargine) injection, prescribing information (DailyMed)U.S. Food and Drug Administration / DailyMed (Eli Lilly and Company label) · 2026dailymed.nlm.nih.govAccessed 2 Oct 2026
  3. 3Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men.The Journal of clinical endocrinology and metabolism · 1992PMID 1379256Accessed 2 Oct 2026
  4. 4Growth Hormone Secretagogue Treatment in Hypogonadal Men Raises Serum Insulin-Like Growth Factor-1 Levels.American journal of men's health · 2017PMID 28830317Accessed 2 Oct 2026
  5. 5Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men.Metabolism: clinical and experimental · 1997PMID 9005976Accessed 2 Oct 2026
  6. 6Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy. Geref International Study Group.The Journal of clinical endocrinology and metabolism · 1996PMID 8772599Accessed 2 Oct 2026
  7. 7Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 1999PMID 18031173Accessed 2 Oct 2026
  8. 8PubMed search: (sermorelin[tiab] OR Geref[tiab]) (34 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  9. 9PubMed search: (sermorelin[tiab] OR "GHRH(1-29)"[tiab] OR "GRF(1-29)"[tiab] OR "GHRH 1-29"[tiab]) AND (elderly[tiab] OR aging[tiab] OR "older adults"[tiab] OR adults[tiab]) AND (treatment[tiab] OR therapy[tiab] OR administration[tiab]) (15 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  10. 10PubMed search: (sermorelin[tiab] OR Geref[tiab]) AND (half-life[tiab] OR pharmacokinetic*[tiab]) (2 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026

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