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Does sermorelin work?

It depends on the outcome: in children with growth hormone deficiency, daily sermorelin-type GHRH roughly doubled height velocity in an open-label trial with no control group.

GHRH analogUpdated

Short answer

It depends on the outcome: in children with growth hormone deficiency, daily sermorelin-type GHRH roughly doubled height velocity in an open-label trial with no control group.[1]

In healthy older men, twice-daily GHRH injections over a short period brought growth hormone and IGF-I levels to those of young men; the authors only suggest that longer treatment could change body composition.[2]

In older men given GHRH nightly for a short course, nocturnal growth hormone release rose but weight, BMI and DEXA fat and muscle did not change.[3]

What the evidence does not show

A review of the sermorelin trials notes sermorelin has not been compared head to head with somatropin, and that its height-velocity gains in children were smaller than those on somatropin.[4]

Common questions

Does sermorelin work for adults?

The adult studies cited are small and in men, and they reported hormone changes with mixed functional results.[3]

More questions on Sermorelin

Can sermorelin make you taller?Does sermorelin build muscle?Does sermorelin cause weight gain?Does sermorelin help with weight loss?Is sermorelin a GLP-1?Is sermorelin a peptide?

More on Sermorelin

ResultsStudy outcomes and when they were measured.Sermorelin overview

Sources

  1. 1Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy. Geref International Study Group.The Journal of clinical endocrinology and metabolism · 1996PMID 8772599Accessed 2 Oct 2026
  2. 2Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men.The Journal of clinical endocrinology and metabolism · 1992PMID 1379256Accessed 2 Oct 2026
  3. 3Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men.Metabolism: clinical and experimental · 1997PMID 9005976Accessed 2 Oct 2026
  4. 4Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 1999PMID 18031173Accessed 2 Oct 2026

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