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Does sermorelin cause weight gain?

None of the studies found reported weight gain. In older men, weight and body mass index did not change over a short course of nightly GHRH.

GHRH analogUpdated

Short answer

None of the studies found reported weight gain. In older men, weight and body mass index did not change over a short course of nightly GHRH.[1]

The trial was short and small, so it cannot rule out later weight change.[1]

In children treated for up to a year, the authors reported no adverse changes in clinical chemistry and no change in fasting glucose.[2]

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Sources

  1. 1Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men.Metabolism: clinical and experimental · 1997PMID 9005976Accessed 2 Oct 2026
  2. 2Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy. Geref International Study Group.The Journal of clinical endocrinology and metabolism · 1996PMID 8772599Accessed 2 Oct 2026

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