Does sermorelin help with weight loss?
No. The only trial measuring weight and fat found no change after a short course of nightly GHRH in older men.
GHRH analogUpdated
Short answer
No. The only trial measuring weight and fat found no change after a short course of nightly GHRH in older men.[1]
The chart review of men seeking fat loss gave sermorelin together with GHRP-6 and GHRP-2, so it cannot show sermorelin's own effect.[2]
A recent narrative review says there is no regulatory approval of this class for physique or performance uses.[3]
More questions on Sermorelin
More on Sermorelin
Sources
- 1Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men.Metabolism: clinical and experimental · 1997PMID 9005976Accessed 2 Oct 2026
- 2Growth Hormone Secretagogue Treatment in Hypogonadal Men Raises Serum Insulin-Like Growth Factor-1 Levels.American journal of men's health · 2017PMID 28830317Accessed 2 Oct 2026
- 3The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.Frontiers in endocrinology · 2026PMID 42395176Accessed 2 Oct 2026
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