What does sermorelin do for men?
In trials in men, sermorelin-type GHRH raised growth hormone secretion; in healthy older men twice-daily injections over a short period brought GH and IGF-I to young-adult levels.
Short answer
In trials in men, sermorelin-type GHRH raised growth hormone secretion; in healthy older men twice-daily injections over a short period brought GH and IGF-I to young-adult levels.[1]
A trial in older men found some strength and endurance measures improved, though most strength measures did not.[2]
A retrospective review of men on testosterone therapy found higher IGF-1 after a combination that included sermorelin; it did not test sermorelin alone.[3]
Common questions
Is sermorelin approved for men?
Its approved use was in children with growth hormone deficiency, and it is no longer marketed in the US.[4]
More questions on Sermorelin
More on Sermorelin
Sources
- 1Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men.The Journal of clinical endocrinology and metabolism · 1992PMID 1379256Accessed 2 Oct 2026
- 2Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men.Metabolism: clinical and experimental · 1997PMID 9005976Accessed 2 Oct 2026
- 3Growth Hormone Secretagogue Treatment in Hypogonadal Men Raises Serum Insulin-Like Growth Factor-1 Levels.American journal of men's health · 2017PMID 28830317Accessed 2 Oct 2026
- 4Clinical review: Is lack of recombinant growth hormone (GH)-releasing hormone in the United States a setback or time to consider glucagon testing for adult GH deficiency?The Journal of clinical endocrinology and metabolism · 2009PMID 19509104Accessed 2 Oct 2026
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