Selank and Semax Together: What Is Known
Selank and Semax taken together: what each one is, how each is regulated, and what is known about combining them.
Medically reviewed by Juan Pablo Frías, MD · · DisclosureUpdated
Interaction notes
Timing, interactions and safety
Evidence for the combination
- Human fMRI study in 52 healthy volunteers comparing Selank, Semax and placebo injections. · PMID 32342318
- Rat study testing Semax and Selank side by side in a Parkinson-like model. Animal data only. · PMID 28702721
- In-vitro comparison of Semax and Selank on enkephalin-degrading enzymes in human serum. · PMID 11443939
Semax is not FDA approved. The studies above describe research settings, not a recommendation to combine them. Ask the prescriber who manages both.
Each component
Side by side
Showing 7 of 11 fields where the two differ. Category, WADA, Half-life, Evidence strength are the same or both unknown.
| Field | Selank | Semax |
|---|---|---|
| Class | Tuftsin analog | ACTH(4-10) analog |
| Also called | — | semax nasal |
| Category | Cognitive & sleep | Cognitive & sleep |
| FDA status | Not FDA approved · research chemical | PCAC voted 8–5 for 503A (Jul 2026) |
| PCAC vote, Jul 2026 | Not on the Jul 2026 agenda | PCAC voted 8–5 for the 503A list (Jul 2026); not finalized |
| WADA | WADA status unclearSelank: This is not named on the 2026 list. The catch-all class S0 prohibits any drug with no approval anywhere for human use, so it would be banned if no health authority has approved it, but we have not verified that for this substance. | WADA status unclearSemax: This is not named on the 2026 list. The catch-all class S0 prohibits any drug with no approval anywhere for human use, so it would be banned if no health authority has approved it, but we have not verified that for this substance. |
| Half-life | No published half-life foundPubMed search, 2 Oct 2026 | No published half-life foundPubMed search, 2 Oct 2026 |
| Evidence strength | Human RCT evidence, 4 of 4Strongest: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 2015, PMID 26356395 | Human RCT evidence, 4 of 4Strongest: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 2018, PMID 29798983 |
| Human studies we summarised | 4 human (3 randomized or controlled) of 15 summarised | 6 human (5 randomized or controlled) of 15 summarised |
| Typical study doses |
|
|
| Vial sizes sold | 5 mg, 10 mg | 5 mg, 10 mg, 30 mg |
Related tools
Selank vs Semax
Choosing between the two rather than combining them? The comparison lines them up field by field.
What people search
- selank semax blend390/mo
- semax selank dosage170/mo
- semax selank stack40/mo
US monthly searches, Google Keyword Planner, Oct 2026. Shown so you can see which questions this page answers.
Sources
- 1FDA gives notice that 12 peptides will be removed from Category 2 (nominations withdrawn)FDA · 2026fda.govAccessed 2 Oct 2026
- 2World Anti-Doping Code International Standard Prohibited List 2026World Anti-Doping Agency · 2026wada-ama.orgAccessed 2 Oct 2026
- 3[Optimization of the treatment of anxiety disorders with selank].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2015PMID 26356395Accessed 2 Oct 2026
- 4Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats.Bulletin of experimental biology and medicine · 2019PMID 31625062Accessed 2 Oct 2026
- 5[COMPARISON OF PHARMACOLOGICAL EFFECTS OF HEPTAPEPTIDE SELANK AFTER INTRANASAL AND INTRAPERITONEAL ADMINISTRATION TO BALB/c AND C57BL/6 MICE.].Eksperimental'naia i klinicheskaia farmakologiia · 2016PMID 29787664Accessed 2 Oct 2026
- 6[Experimental optimization of learning and memory processes by selank].Eksperimental'naia i klinicheskaia farmakologiia · 2010PMID 20919548Accessed 2 Oct 2026
- 7PubMed search: selank[tiab] (68 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
- 8PubMed search: selank[tiab] AND (half-life[tiab] OR pharmacokinetic*[tiab]) (4 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
- 9PubMed search: (selank[tiab] OR semax[tiab]) AND (randomized[tiab] OR patients[tiab] OR clinical[tiab]) (48 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
- 10[The efficacy of semax in the tretament of patients at different stages of ischemic stroke].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2018PMID 29798983Accessed 2 Oct 2026
- 11Effects of Semax on the Default Mode Network of the Brain.Bulletin of experimental biology and medicine · 2018PMID 30225715Accessed 2 Oct 2026
- 12Therapy of peptic ulcer with semax peptide.Bulletin of experimental biology and medicine · 2002PMID 12459874Accessed 2 Oct 2026
- 13PubMed search: semax[tiab] (208 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
- 14PubMed search: semax[tiab] AND (half-life[tiab] OR pharmacokinetic*[tiab]) (4 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
- 15PubMed search: (selank[tiab]) AND (semax[tiab])PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
- 16Functional Connectomic Approach to Studying Selank and Semax Effects.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2020PMID 32342318Accessed 2 Oct 2026
- 17Peptides semax and selank affect the behavior of rats with 6-OHDA induced PD-like parkinsonism.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2017PMID 28702721Accessed 2 Oct 2026
- 18[Semax and selank inhibit the enkephalin-degrading enzymes from human serum]].Bioorganicheskaia khimiia · 2001PMID 11443939Accessed 2 Oct 2026
- 19[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2008PMID 18454096Accessed 2 Oct 2026
- 20Advisory committee backs 6 of 7 peptides for the 503A listNCPA · 2026ncpa.org
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