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Semax

ACTH(4-10) analog. Semax is not FDA approved for any use.

Also called:semax nasal
Medically reviewed by Juan Pablo Frías, MD · · DisclosureUpdated Strongest evidence: Human RCT evidence, 4 of 4
StatusPCAC voted 8–5 for 503A (Jul 2026)Removed from FDA Category 2 on 15 Apr 2026. PCAC voted 8–5 for the 503A list (Jul 2026); not finalized.WADA status unclearFull legal history

Key facts

How we verify
Class
ACTH(4-10) analog
Also called
semax nasal
Vial sizes sold
5 mg, 10 mg, 30 mg
Community-reported sizes
Half-life
Not found
No published half-life found (PubMed search, 2 Oct 2026)
FDA status
Not approved
Off Category 2, 15 Apr 2026
PCAC vote
8–5 for 503A
Jul 2026, not final
WADA
Unclear
Not named on the 2026 list
Everything on Semax

Semax guides

DosageDoses used in published studies, with the source for each.ResultsStudy outcomes and when they were measured.CalculatorVial, water and dose to syringe units.PricePrice per mg and per week from dated listings. No vendor links.Legal statusFDA, compounding and WADA status with dates.Half-lifeWhat is measured, by route, and what is not.StoragePowder and mixed vials: temperature and shelf life.For ADHDWhat research says about Semax for ADHD.

Evidence at a glance

Human and animal counts are PubMed records from our evidence ledger (search counts, not studies we reviewed). The grade is the strongest design among the studies we summarised for that goal: a human randomized trial outweighs any number of animal studies.

Semax: studies by condition
ConditionHuman studiesAnimal studiesStudies we summarisedEvidence grade
ADHD101No graded study for this goal

Grades follow our evidence scale. Summarised studies come from our evidence file, each quote checked against the abstract or label.

Compared with

SemaxvsSelankACTH(4-10) analog next to tuftsin analog: evidence, dosing and legal status side by side.Not FDA approved · research chemicalRead the comparison →

Common stacks

Semax is often sold pre-mixed or combined with other peptides. A few of these pairs appear together in published studies; each stack page lists what was tested, and the pages below cover the math and what each part has been studied for.

Semax + Selank

Common questions

Is Semax FDA approved?

No. Semax is not FDA approved for any use. The FDA removed it from Category 2 on 15 Apr 2026. Its advisory committee voted 8–5 in July 2026 to add it to the 503A compounding list. That vote is not final.

How much water goes in a 10 mg vial?

That choice only changes the concentration. With 2 mL, the vial is 5 mg/mL. The calculator converts any amount to syringe units. It does the math only and does not suggest a dose.

Sources

  1. 1Certain bulk drug substances for use in compounding that may present significant safety risks (Category 2; 'nominated but withdrawn' table, content current as of 22 Apr 2026)U.S. Food and Drug Administration · 2026fda.govAccessed 2 Oct 2026
  2. 2Pharmacy Compounding Advisory Committee meeting, 23–24 Jul 2026 (agenda and materials)U.S. Food and Drug Administration · 2026fda.govAccessed 2 Oct 2026
  3. 3US search volume and year-over-year trend, Google Keyword Planner export (Jun–Aug 2026 vs 2025)Peptigraph research · 2026peptigraph.com/methodology/Accessed 1 Oct 2026
  4. 4World Anti-Doping Code International Standard Prohibited List 2026World Anti-Doping Agency · 2026wada-ama.orgAccessed 2 Oct 2026
  5. 5United States: No FDA-approved product found: Drugs@FDA (openFDA) search for active ingredient "semax" returned no matches on 2 Oct 2026.U.S. Food and Drug Administration · 2026api.fda.govAccessed 2 Oct 2026
  6. 6US compounding: Semax was removed from FDA's 503A category 2 after the nominators withdrew; FDA announced a PCAC consultation on 24 July 2026.U.S. Food and Drug Administration · 2026fda.govAccessed 2 Oct 2026
  7. 7[The efficacy of semax in the tretament of patients at different stages of ischemic stroke].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2018PMID 29798983Accessed 2 Oct 2026
  8. 8PubMed search: semax[tiab] (208 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  9. 9PubMed search: semax[tiab] AND (half-life[tiab] OR pharmacokinetic*[tiab]) (4 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  10. 10PubMed search: (selank[tiab] OR semax[tiab]) AND (randomized[tiab] OR patients[tiab] OR clinical[tiab]) (48 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  11. 11Advisory committee backs 6 of 7 peptides for the 503A listNCPA · 2026ncpa.org
  12. 12FDA gives notice that 12 peptides will be removed from Category 2 (nominations withdrawn)FDA · 2026fda.govAccessed 2 Oct 2026

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