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KPV reconstitution calculator

Medically reviewed by Juan Pablo Frías, MD · · DisclosureUpdated Educational use only
1Vial size
2Bacteriostatic water added
3Dose per injection
4Syringe (U-100)
Draw to
10units
= 0.1 mL on a 1 mL U-100 insulin syringe
10 mg vial2 mL water500 mcg dose
Concentration
5 mg/mL
Doses per vial
20
Weeks (1 dose/wk)
20
Math only. It does not recommend a dose. KPV: PCAC voted 8–6 for 503A (Jul 2026).

10 units (0.1 mL) on a 1 mL U-100 syringe: 500 mcg from a 10 mg vial + 2 mL water (KPV).

Dosing table for a 10 mg vial

Syringe units (U-100) for each dose, by how much bacteriostatic water you add.

KPV: U-100 syringe units per dose for a 10 mg vial
Dose1 mL water2 mL water2.5 mL water3 mL water
100 mcg122.53
200 mcg2456
250 mcg2.556.257.5
500 mcg51012.515
750 mcg7.51518.7522.5
1000 mcg10202530

How the math works

Concentration is the vial's milligrams divided by the water you add. Volume to draw is your dose divided by that concentration. On a U-100 syringe, 1 mL is 100 units, so units = mL × 100.

10 mg ÷ 2 mL = 5 mg/mL
500 mcg = 0.5 mg; 0.5 mg ÷ 5 mg/mL = 0.1 mL
0.1 mL × 100 = 10 units

How many units is 500 mcg of KPV?

With a 10 mg vial and 2 mL of bacteriostatic water, 500 mcg is 10 units (0.10 mL) on a U-100 syringe. With 1 mL of water it is 5 units. The answer always depends on how much water was added.

How much bacteriostatic water for a 10 mg KPV vial?

The water only sets the concentration; the amount of KPV in the vial stays the same. 2 mL makes 5 mg/mL, so 500 mcg is 10 units. 2.5 mL makes 4 mg/mL, so the same 500 mcg is 12.5 units. More water makes small doses easier to measure but needs more volume per injection.

How many 500 mcg doses are in a 10 mg vial?

10 mg is 10,000 mcg; 10,000 ÷ 500 = 20, so 20 full doses of 500 mcg. Any liquid lost in the needle and vial is not counted.

Preset doses are round numbers for the arithmetic, not dosing guidance. Vial sizes are the ones most often mentioned for KPV in community discussions.

10 units · 0.1 mL · 500 mcg from 10 mg + 2 mL

Sources

  1. 1Metric (SI) Prefixes (NIST Reference on Constants, Units, and Uncertainty)National Institute of Standards and Technology (NIST) · 2025physics.nist.govAccessed 2 Oct 2026
  2. 2BASAGLAR (insulin glargine) injection, prescribing information (DailyMed)U.S. Food and Drug Administration / DailyMed (Eli Lilly and Company label) · 2026dailymed.nlm.nih.govAccessed 2 Oct 2026

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