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How CJC-1295 Works: Mechanism and Pharmacology

How CJC-1295 works: its target and mechanism as the sources state them, how long it acts, and what is still unknown.

Medical review pendingGHRH analogUpdated
Class
GHRH analog
FDA status
Not approved
research chemical
Routes studied
subcutaneous; injection (route not stated in abstract); not stated
Half-life
[pending]
by route, with source

How long it acts

No published half-life found for CJC-1295 (PubMed search, 11 Oct 2026)

Full detail, including drug-testing windows, is on the CJC-1295 half-life page.

The pathway CJC-1295 uses

GHRH is made in the hypothalamus and binds receptors on pituitary somatotropes to promote the synthesis and release of GH.[4]

A mouse paper describes CJC-1295 as a synthetic GHRH analog that binds covalently to albumin after injection, extending its half-life and duration of action.[5]

In rats, a Western blot found a CJC-1295 immunoreactive species on the albumin band, appearing after 15 minutes and remaining beyond 24 hours.[6]

What happens to the GH pulse pattern

With CJC-1295 on board, pulses stayed regular while trough GH levels rose, which the authors link to higher IGF-I.[7]

In knockout mice, CJC-1295 increased pituitary RNA and GH mRNA, suggesting somatotroph proliferation; this is mouse data.[5]

In a serum-protein study of young men, the intensity of a spot holding immunoglobulin and albumin fragments tracked IGF-1 levels in a linear relationship.[4]

Why it is described as long-acting

The human single-dose study estimated the half-life of CJC-1295 at 5.8 to 8.1 days.[8]

In rats, CJC-1295 was found in plasma beyond 72 hours.[6]

The pulsatility study cited a half-life of 8 days for the albumin-bound analog.[7]

What is not shown

A mechanism check of the 7 cached abstracts found 0 label statements of mechanism, since CJC-1295 has no approved label, and 0 human studies that measured receptor binding directly.

Calculated from abstracts checked 7; label mechanism statements 0; human receptor binding studies 0. Formula: count of cached sources stating the item

Related peptides

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Common questions

How long does CJC-1295 act in the body?

We found no published half-life for CJC-1295 (PubMed search, 11 Oct 2026), so how long it acts is unknown.

How does CJC-1295 work?

CJC-1295 is a GHRH analog that binds albumin to extend its life and stimulates the pituitary to release growth hormone.[5]

Does CJC-1295 work?

In healthy adults it raised GH and IGF-I; the cached trials did not test clinical benefits.[7]

More on CJC-1295

DosageDoses used in published studies, with the source for each.CalculatorVial, water and dose to syringe units.Side effectsWhat labels and studies report, and what is unknown.ResultsStudy outcomes and when they were measured.PricePrice per mg and per week from dated listings. No vendor links.BenefitsClaimed benefits next to what published studies measured.

Sources

  1. 1PubMed search: ("CJC-1295"[tiab] OR CJC1295[tiab]) (33 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  2. 2PubMed search: ("CJC-1295"[tiab] OR CJC1295[tiab]) AND (half-life[tiab] OR pharmacokinetic*[tiab]) (7 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  3. 3PubMed search: ("CJC-1295"[tiab] OR CJC1295[tiab]) AND (adverse[tiab] OR "side effect*"[tiab] OR safety[tiab] OR tolerab*[tiab] OR toxicity[tiab] OR "case report"[pt]) (11 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 11 Oct 2026
  4. 4Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2009PMID 19386527Accessed 2 Oct 2026
  5. 5Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse.American journal of physiology. Endocrinology and metabolism · 2006PMID 16822960Accessed 2 Oct 2026
  6. 6Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog.Endocrinology · 2005PMID 15817669Accessed 2 Oct 2026
  7. 7Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog.The Journal of clinical endocrinology and metabolism · 2006PMID 17018654Accessed 2 Oct 2026
  8. 8Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.The Journal of clinical endocrinology and metabolism · 2006PMID 16352683Accessed 2 Oct 2026

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