Does CJC-1295 work?
It works on its target hormones: in placebo-controlled trials in healthy adults, a single injection raised growth hormone 2- to 10-fold for 6 d or more and IGF-I 1.5- to 3-fold for 9-11 d.
Short answer
It works on its target hormones: in placebo-controlled trials in healthy adults, a single injection raised growth hormone 2- to 10-fold for 6 d or more and IGF-I 1.5- to 3-fold for 9-11 d.[1]
Those trials measured hormone levels, not body weight, muscle or athletic outcomes.[1]
In young men, the rise in GH was mostly in baseline (trough) levels, while the size and number of GH pulses did not change.[2]
In mice lacking the GHRH gene, daily CJC-1295 kept growth and body composition normal, while less frequent dosing worked less well.[3]
Common questions
How does CJC-1295 work?
In rat pituitary cells and rats, it is a modified GRF (1-29) that binds albumin, giving it a longer-lasting GH-releasing action than the unmodified sequence.[4]
More on CJC-1295
Sources
- 1Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.The Journal of clinical endocrinology and metabolism · 2006PMID 16352683Accessed 2 Oct 2026
- 2Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog.The Journal of clinical endocrinology and metabolism · 2006PMID 17018654Accessed 2 Oct 2026
- 3Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse.American journal of physiology. Endocrinology and metabolism · 2006PMID 16822960Accessed 2 Oct 2026
- 4Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog.Endocrinology · 2005PMID 15817669Accessed 2 Oct 2026
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