Dihexa Results: What Studies Measured and When
What published studies measured for Dihexa, when those outcomes were measured, and what is still unproven.
What studies measured
Each outcome below comes from a published study, with its type and size, strongest design first. Animal and cell results are labelled as such and are not human results.
| Outcome | Result | Study type | Source |
|---|---|---|---|
| Huntington-like deficits | Dihexa (PNB-0408) did not protect rats from 3-NP-induced motor and cognitive deficits. | Animal · rat (not a human result)n = 40 | Journal of Huntington's disease 2024, PMID 38489193 |
| Spatial learning | Dihexa restored spatial learning and cognitive function in the Morris water maze in a transgenic Alzheimer mouse model. | Animal · mouse (not a human result) | Brain sciences 2021, PMID 34827486 |
| Neuroinflammation | Dihexa reduced glial activation and pro-inflammatory cytokines and raised IL-10 in the mouse brain. | Animal · mouse (not a human result) | Brain sciences 2021, PMID 34827486 |
| Limb motor recovery | Motor function improved at 8-16 weeks with MSC plus dihexa (and MSC plus G-CSF) given into muscle; dihexa alone was not singled out. | Animal · rat (not a human result) | Annals of medicine and surgery 2021, PMID 34703584 |
| Hair cell protection | 1 μM dihexa gave optimal protection of hair cells against neomycin or gentamicin. | Animal · zebrafish larva (not a human result) | Frontiers in cellular neuroscience 2015, PMID 25674052 |
| Antidementia activity (scopolamine and aged rats) | Dihexa, an orally active blood-brain-barrier-permeant analog, showed antidementia activity in scopolamine and aged rat models and marked synaptogenic activity. | Animal · rat (not a human result) | The Journal of pharmacology and experimental therapeutics 2013, PMID 23055539 |
- No human study of dihexa has been published in PubMed as of 2 October 2026. Every study here is in rodents or zebrafish; there are no human pharmacokinetic, safety or efficacy data.
- A 2014 mechanism paper (PMID 25187433) has been retracted and is not used.
- One rat study (Huntington-like model) found no protective effect, so the animal evidence is not uniformly positive.
- Oral and blood-brain-barrier-permeant claims for dihexa come from a 2013 rat paper; no half-life or plasma concentration was found.
- Dihexa is not FDA-approved and has no label.
Typical timeline
When measurable changes appeared in studies of Dihexa: not reported in study abstracts (PubMed search, 2 Oct 2026).
Before-and-after photos
We don't publish before-and-after photos. They can't be verified, rarely show dose, diet or other drugs, and only the most dramatic results get posted.
Common questions
How long does Dihexa take to work?
The study abstracts we summarised for Dihexa do not report when outcomes were measured (PubMed search, 2 Oct 2026).
Do you show Dihexa before and after photos?
No. Photos can't be verified, rarely show dose, diet or other drugs, and only the most dramatic ones get posted. We summarize measured outcomes instead.
More on Dihexa
Sources
- 1Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats.Journal of Huntington's disease · 2024PMID 38489193Accessed 2 Oct 2026
- 2AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway.Brain sciences · 2021PMID 34827486Accessed 2 Oct 2026
- 3Stem cell, Granulocyte-Colony Stimulating Factor and/or Dihexa to promote limb function recovery in a rat sciatic nerve damage-repair model: Experimental animal studies.Annals of medicine and surgery (2012) · 2021PMID 34703584Accessed 2 Oct 2026
- 4Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure.Frontiers in cellular neuroscience · 2015PMID 25674052Accessed 2 Oct 2026
- 5Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents.The Journal of pharmacology and experimental therapeutics · 2013PMID 23055539Accessed 2 Oct 2026
- 6PubMed search: dihexa[tiab] OR "N-hexanoic-Tyr-Ile-(6) aminohexanoic amide"[tiab] (17 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
- 7PubMed search: "N-hexanoic-Tyr-Ile-(6) aminohexanoic amide"[tiab] OR "Nle1-angiotensin IV"[tiab] OR "angiotensin IV analog"[tiab] OR "AngIV analog"[tiab] (14 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
- 8PubMed search: (dihexa[tiab] OR "hepatocyte growth factor"[tiab]) AND (mimetic[tiab] OR "angiotensin IV"[tiab] OR Nle[tiab]) AND (memory[tiab] OR cognit*[tiab]) (7 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
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