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IGF-1 LR3

IGF-1 analog. IGF-1 LR3 is Not FDA approved · research chemical; research-chemical versions are not the approved drug.

Also called:LR3
Medically reviewed by Juan Pablo Frías, MD · · DisclosureUpdated Strongest evidence: Human observational evidence, 3 of 4
StatusNot FDA approved · research chemicalProhibited by WADA (S2.3)Full legal history

Key facts

How we verify
Class
IGF-1 analog
Also called
LR3
Vial sizes sold
0.1 mg, 1 mg
Community-reported sizes
Half-life
563 min half-life in wound fluid (versus 872 min for IGF-I)
wound chamber (rat), rat · The American journal of physiology 1999, PMID 10198302
FDA status
Not FDA approved · research chemical
No approved product found
WADA
Prohibited (S2.3)
In and out of competition
Everything on IGF-1 LR3

IGF-1 LR3 guides

DosageDoses used in published studies, with the source for each.Side effectsWhat labels and studies report, and what is unknown.CalculatorVial, water and dose to syringe units.ResultsStudy outcomes and when they were measured.PricePrice per mg and per week from dated listings. No vendor links.How to injectSites, syringe types and hygiene, step by step.1 mg vialConcentration and unit tables for the 1 mg size.For muscle growthWhat research says about IGF-1 LR3 for muscle growth.For weight lossWhat research says about IGF-1 LR3 for weight loss.

Evidence at a glance

Human and animal counts are PubMed records from our evidence ledger (search counts, not studies we reviewed). The grade is the strongest design among the studies we summarised for that goal: a human randomized trial outweighs any number of animal studies.

IGF-1 LR3: studies by condition
ConditionHuman studiesAnimal studiesStudies we summarisedEvidence grade
Muscle growth068Animal evidence, 2 of 4American journal of physiology. Endocrinology and metabolism 2025, PMID 39679943
Weight lossNot in our ledgerNot in our ledger0No graded study for this goal

Grades follow our evidence scale. Summarised studies come from our evidence file, each quote checked against the abstract or label.

Compared with

IGF-1 LR3vsCJC-1295 + IpamorelinIGF-1 analog next to ghrh + ghrp blend: evidence, dosing and legal status side by side.Not FDA approved · research blendRead the comparison →IGF-1 LR3vsTesamorelinIGF-1 analog next to ghrh analog: evidence, dosing and legal status side by side.FDA approved (Egrifta)Read the comparison →IGF-1 LR3vsHGHIGF-1 analog next to recombinant growth hormone: evidence, dosing and legal status side by side.FDA approved (prescription only)Read the comparison →IGF-1 LR3vsCJC-1295IGF-1 analog next to ghrh analog: evidence, dosing and legal status side by side.Not FDA approved · research chemicalRead the comparison →

Common stacks

IGF-1 LR3 is often sold pre-mixed or combined with other peptides. No controlled study has tested these combinations; the pages below cover the math and what each part has been studied for.

IGF-1 LR3 + CJC-1295 + IpamorelinIGF-1 LR3 + HGHIGF-1 LR3 + Tesamorelin

Common questions

Is IGF-1 LR3 FDA approved?

IGF-1 LR3 is Not FDA approved · research chemical. Products sold as research chemicals are not the approved drug and are not checked by the FDA.

Is IGF-1 LR3 banned in sport?

Yes. Prohibited by WADA (S2.3), so it is prohibited at all times for tested athletes.

How much water goes in a 1 mg vial?

That choice only changes the concentration. With 2 mL, the vial is 0.5 mg/mL. The calculator converts any amount to syringe units. It does the math only and does not suggest a dose.

Sources

  1. 1US search volume and year-over-year trend, Google Keyword Planner export (Jun–Aug 2026 vs 2025)Peptigraph research · 2026peptigraph.com/methodology/Accessed 1 Oct 2026
  2. 2World Anti-Doping Code International Standard Prohibited List 2026World Anti-Doping Agency · 2026wada-ama.orgAccessed 2 Oct 2026
  3. 3United States: No FDA-approved product found: Drugs@FDA (openFDA) search for active ingredient "IGF-1 LR3" returned no matches on 2 Oct 2026.U.S. Food and Drug Administration · 2026api.fda.govAccessed 2 Oct 2026
  4. 4IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep.American journal of physiology. Endocrinology and metabolism · 2025PMID 39679943Accessed 2 Oct 2026
  5. 5Detection of His-tagged Long-R³-IGF-I in a black market product.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2010PMID 20675162Accessed 2 Oct 2026
  6. 6Clearance of IGFs and insulin from wounds: effect of IGF-binding protein interactions.The American journal of physiology · 1999PMID 10198302Accessed 2 Oct 2026
  7. 7PubMed search: ("Long R3"[tiab] OR (LR3[tiab] AND (IGF[tiab] OR "IGF-1"[tiab] OR "IGF-I"[tiab] OR "insulin-like growth factor"[tiab]))) (109 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  8. 8PubMed search: ("Long R3 IGF-I"[tiab] OR "LR3 IGF-I"[tiab] OR "IGF-I LR3"[tiab] OR "LR3-IGF-I"[tiab] OR "IGF-1 LR3"[tiab] OR "LR3 IGF-1"[tiab] OR "[Long R3]IGF-I"[tiab]) AND (rat[tiab] OR rats[tiab] OR mice[tiab] OR infusion[tiab] OR muscle[tiab] OR pigs[tiab] OR in vivo[tiab]) (38 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  9. 9PubMed search: "long R3 IGF"[tiab] OR "long-R3 IGF"[tiab] OR "LR3-IGF"[tiab] OR "LR3 IGF"[tiab] OR "R3 IGF-I"[tiab] (95 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  10. 10PubMed search: ("LR3"[tiab] AND IGF[tiab]) AND (half-life[tiab] OR pharmacokinetic*[tiab] OR clearance[tiab]) (2 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026

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