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IGF-1 LR3 Dosage: Doses Studied, Units and Chart

What doses of IGF-1 LR3 have been used in published research, how they convert to syringe units, and what is still unknown.

Medically reviewed by Juan Pablo Frías, MD · · DisclosureIGF-1 analogUpdated
Doses studied
8 studies
with a stated dose, listed below
Frequency
Varies by study
as used in studies
Half-life
563 min half-life in wound fluid (versus 872 min for IGF-I)
wound chamber (rat), rat · The American journal of physiology 1999, PMID 10198302
Vial sizes sold
0.1 mg, 1 mg

Doses used in published studies

Each dose below is quoted from a study abstract, strongest design first. Animal doses are labelled and do not translate directly to people. None of them is a recommendation.

Doses of IGF-1 LR3 used in published studies
DoseFrequency and routeStudy typeSource
1.17 ± 0.12 μg·kg-1·h-1continuous · fetal infusion · 1 wkAnimal · sheep (not a human result)n = 14American journal of physiology. Endocrinology and metabolism 2025, PMID 39679943
not statednot stated · intranasal · 7 monthsAnimal · mouse (not a human result)Journal of Alzheimer's disease 2025, PMID 39610283
2, 4 or 8 microg/h (Expt 1); 8 then 16 microg/h (Expt 2)continuous · infusion · 8 d (Expt 1); 18 d (Expt 2)Animal · pig (not a human result)The British journal of nutrition 2002, PMID 12067429
180 micrograms/kg/daycontinuous · infusion · 4 daysAnimal · pig (not a human result)The Journal of endocrinology 1997, PMID 9488001
120 micrograms/day LR3IGF-Icontinuous · continuous infusion · 7 daysAnimal · guinea pig (not a human result)The Journal of endocrinology 1995, PMID 7561636
2.5 mg/kg/daycontinuous · infusion · 3 daysAnimal · rat (not a human result)Gut 1995, PMID 8549937
200 or 500 microgram/daycontinuous · infusion by osmotic minipump · 6-7 daysAnimal · rat (not a human result)The Biochemical journal 1994, PMID 8053901
Graded doses up to 695 micrograms/day (IGF-I)continuous · infusion by mini-osmotic pump · 7 daysAnimal · rat (not a human result)The Biochemical journal 1993, PMID 7683875

Dose to syringe units

For a 1 mg vial mixed with 2 mL of bacteriostatic water (0.5 mg/mL), on a U-100 syringe. These are reference amounts for the math, not suggested doses.

10 mcg
2 u
20 mcg
4 u
50 mcg
10 u
100 mcg
20 u
Use your own vial and water

Before anyone considers it

  • IGF-1 LR3 is Not FDA approved · research chemical; research-chemical versions are not the approved drug.
  • Compounded and research-chemical versions are not the approved product and are not checked by the FDA for identity, purity or dose.
  • Reconstitution math (mg vs mcg, units vs mL) is the most asked question in peptide forums. Check every number twice.
  • People who are pregnant, breastfeeding, or have a chronic condition need medical advice first.

Common questions

How many units is 50 mcg of IGF-1 LR3?

It depends on the water added. A 1 mg vial with 2 mL of water gives 0.5 mg/mL, so 50 mcg is 10 units on a U-100 syringe. Use the calculator for other mixes.

Is IGF-1 LR3 FDA approved?

IGF-1 LR3 is Not FDA approved · research chemical. Products sold as research chemicals are not the approved drug and are not checked by the FDA.

More on IGF-1 LR3

Side effectsWhat labels and studies report, and what is unknown.CalculatorVial, water and dose to syringe units.ResultsStudy outcomes and when they were measured.PricePrice per mg and per week from dated listings. No vendor links.How to injectSites, syringe types and hygiene, step by step.1 mg vialConcentration and unit tables for the 1 mg size.

Sources

  1. 1Metric (SI) Prefixes (NIST Reference on Constants, Units, and Uncertainty)National Institute of Standards and Technology (NIST) · 2025physics.nist.govAccessed 2 Oct 2026
  2. 2BASAGLAR (insulin glargine) injection, prescribing information (DailyMed)U.S. Food and Drug Administration / DailyMed (Eli Lilly and Company label) · 2026dailymed.nlm.nih.govAccessed 2 Oct 2026
  3. 3IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep.American journal of physiology. Endocrinology and metabolism · 2025PMID 39679943Accessed 2 Oct 2026
  4. 4Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice.Journal of Alzheimer's disease : JAD · 2025PMID 39610283Accessed 2 Oct 2026
  5. 5Insulin-like growth factor-I and analogues increase growth in artificially-reared neonatal pigs.The British journal of nutrition · 2002PMID 12067429Accessed 2 Oct 2026
  6. 6Long [R3] insulin-like growth factor-I reduces growth, plasma growth hormone, IGF binding protein-3 and endogenous IGF-I concentrations in pigs.The Journal of endocrinology · 1997PMID 9488001Accessed 2 Oct 2026
  7. 7Long R3 insulin-like growth factor-I (IGF-I) infusion stimulates organ growth but reduces plasma IGF-I, IGF-II and IGF binding protein concentrations in the guinea pig.The Journal of endocrinology · 1995PMID 7561636Accessed 2 Oct 2026
  8. 8Administration of insulin-like growth factor-I (IGF-I) peptides for three days stimulates proliferation of the small intestinal epithelium in rats.Gut · 1995PMID 8549937Accessed 2 Oct 2026
  9. 9Effects of insulin and insulin-like growth factors on protein and energy metabolism in tumour-bearing rats.The Biochemical journal · 1994PMID 8053901Accessed 2 Oct 2026
  10. 10Insulin-like growth factor-I and more potent variants restore growth of diabetic rats without inducing all characteristic insulin effects.The Biochemical journal · 1993PMID 7683875Accessed 2 Oct 2026
  11. 11Clearance of IGFs and insulin from wounds: effect of IGF-binding protein interactions.The American journal of physiology · 1999PMID 10198302Accessed 2 Oct 2026

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