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Does ipamorelin increase appetite?

In rats recovering from surgery, repeated ipamorelin increased food intake and weight gain. This is animal evidence in a postoperative model.

GHRP (ghrelin receptor agonist)Updated

Short answer

In rats recovering from surgery, repeated ipamorelin increased food intake and weight gain. This is animal evidence in a postoperative model.[1]

In the human trial after bowel resection, time to first tolerated meal was 25.3 hours on ipamorelin and 32.6 on placebo, a difference that was not statistically significant (p = 0.15). The measure is meal timing, not an appetite score.[2]

Another animal model

In ferrets given a chemotherapy drug, ipamorelin and a related compound reduced weight loss by about 24% on the last day measured, again an animal result.[3]

More questions on Ipamorelin

Does ipamorelin work?

More on Ipamorelin

ResultsStudy outcomes and when they were measured.Ipamorelin overview

Sources

  1. 1Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus.The Journal of pharmacology and experimental therapeutics · 2009PMID 19289567Accessed 2 Oct 2026
  2. 2Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients.International journal of colorectal disease · 2014PMID 25331030Accessed 2 Oct 2026
  3. 3The growth hormone secretagogue receptor 1a agonists, anamorelin and ipamorelin, inhibit cisplatin-induced weight loss in ferrets: Anamorelin also exhibits anti-emetic effects via a central mechanism.Physiology & behavior · 2024PMID 39043357Accessed 2 Oct 2026

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