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Does MOTS-c burn fat?

Fat burning has not been shown in humans. In mice, MOTS-c prevented obesity from a high-fat diet, which is prevention of gain rather than measured fat loss.

Mitochondrial-derived peptideUpdated

Short answer

Fat burning has not been shown in humans. In mice, MOTS-c prevented obesity from a high-fat diet, which is prevention of gain rather than measured fat loss.[1]

The proposed mechanism is cell-level: the authors say MOTS-c blocks the folate cycle and purine synthesis and so switches on AMPK.[1]

In breast cancer survivors, higher post-exercise natural MOTS-c went with lower fat mass, but this is an association in people who exercised, not an effect of taking the peptide.[2]

More questions on MOTS-c

Does MOTS-c give you energy?Does MOTS-c help with weight loss?

More on MOTS-c

ResultsStudy outcomes and when they were measured.MOTS-c overview

Sources

  1. 1The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.Cell metabolism · 2015PMID 25738459Accessed 2 Oct 2026
  2. 2Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors.Scientific reports · 2021PMID 34413391Accessed 2 Oct 2026

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