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Does MOTS-c help with weight loss?

Not in people. The only treatment results are in mice, where MOTS-c prevented diet-induced obesity.

Mitochondrial-derived peptideUpdated

Short answer

Not in people. The only treatment results are in mice, where MOTS-c prevented diet-induced obesity.[1]

In ovariectomized mice, a model of the postmenopausal state, treatment prevented obesity as well.[2]

In adults, natural serum MOTS-c did not differ between those with obesity and those with normal BMI, so low levels do not explain obesity in that study.[3]

More questions on MOTS-c

Does MOTS-c burn fat?Does MOTS-c give you energy?

More on MOTS-c

ResultsStudy outcomes and when they were measured.MOTS-c overview

Sources

  1. 1The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.Cell metabolism · 2015PMID 25738459Accessed 2 Oct 2026
  2. 2MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction.Journal of molecular medicine (Berlin, Germany) · 2019PMID 30725119Accessed 2 Oct 2026
  3. 3MOTS-C levels ın ındividuals with and without obesity and ıts association with ınflammation, insulin resistance and endothelial dysfunction.Archives of endocrinology and metabolism · 2025PMID 41004666Accessed 2 Oct 2026

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