Peptides for Depression
The peptides people most often research for depression, with how much evidence exists for each. A long list does not mean any of them is proven to work in people.
Medically reviewed by Juan Pablo Frías, MD · · DisclosureUpdated
- Peptides listed
- 3
- With human trials
- 1
- FDA approved (any use)
- 2
- Searches per month
- 1,360
Showing 3 peptides · ordered by search interest for this goal
- SelankTuftsin analogAnimal evidence, 2 of 4Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 2008, PMID 18661785Human2Animal5Summarised1Not FDA approved · research chemicalFor depressionOverview
- SemaxACTH(4-10) analogAnimal evidence, 2 of 4European journal of pharmacology 2024, PMID 39442746Human0Animal6Summarised1PCAC voted 8–5 for 503A (Jul 2026)Overview
- TirzepatideGLP-1 / GIP dual agonistHuman RCT evidence, 4 of 4Obesity 2026, PMID 41537305Human35Animal2Summarised1FDA approved (Mounjaro, Zepbound)For depressionOverview
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What this list does not show
Search demand tells you what people are curious about, not what works. Read each peptide's evidence before anything else.
Search interest is not evidence
This list follows what people search for and discuss. It says nothing about how well any peptide works.Animal results may not carry over
Doses, routes and effects seen in rodents or cell dishes often have no tested human equivalent.Approval covers specific uses
An FDA approval applies to the conditions and doses on the label, not to every goal a drug is searched with.Combinations are a separate question
Blends and stacks put several peptides together. Evidence for one peptide is not evidence for the mix.Related goals
Explore nearby goals
What people search
- peptides for depression880/mo
- peptides for mood210/mo
- best peptide for depression110/mo
- best peptides for depression90/mo
- mood peptides40/mo
- best peptides for mood20/mo
US monthly searches, Google Keyword Planner, Oct 2026. Shown so you can see which questions this page answers.
Sources
- 1[Effects of heptapeptide selank on genetically-based and situation-provoked symptoms of depression in behavior in WAG/Rij and Wistar rats, and in BALB/c mice].Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova · 2008PMID 18661785Accessed 2 Oct 2026
- 2Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress.European journal of pharmacology · 2024PMID 39442746Accessed 2 Oct 2026
- 3Psychiatric Safety of Tirzepatide in People With Obesity and No Known Major Psychopathology: A Post Hoc Analysis of SURMOUNT.Obesity (Silver Spring, Md.) · 2026PMID 41537305Accessed 2 Oct 2026
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