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Selank for Depression: What the Evidence Shows

What human and animal studies show about Selank for depression, how strong that evidence is, and what is still unproven.

Medically reviewed by Juan Pablo Frías, MD · · DisclosureTuftsin analogUpdated
Strongest evidence
Animal
Human studies
2
PubMed records, our ledger
Animal studies
5
PubMed records, our ledger
Studies we summarised
1
with an outcome for depression

Evidence for depression

Each row is an outcome related to depression from a published study, strongest design first. Animal and cell results are labelled and are not human results. User reports are not counted as evidence here.

Selank for depression: outcomes in published studies
OutcomeResultStudy typeSource
Depression-like behaviour in WAG/Rij ratsHigh-dose repeated selank (1000-2000 microg/kg) counteracted depression-like behaviour in WAG/Rij rats.Animal · rat and mouse (not a human result)Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 2008, PMID 18661785
Forced swim test in BALB/c miceA single low dose reduced immobility in mice but repeated or higher doses did not.Animal · rat and mouse (not a human result)Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 2008, PMID 18661785

PubMed records for Selank and depression: 2 human, 5 animal (search counts, not studies we reviewed). Grades follow our evidence scale.

How strong is it?

Strongest evidence:Animal evidence, 2 of 4Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 2008, PMID 18661785

A human randomized trial outweighs any number of animal studies. Animal and cell results show a mechanism worth testing, not that it works in people.

Other peptides people research for depression

TirzepatideSemaglutide
All peptides for depression, compared

Common questions

Does Selank help with depression?

The strongest study we summarise for depression is animal evidence, across 1 study with an outcome for depression. That is not proof it works in people.

Is Selank approved for depression?

Selank is Not FDA approved · research chemical. Which conditions that approval covers is set by the label; use for anything else is off-label.

What is the best peptide for depression?

There is no single answer. Our depression overview compares each candidate by evidence grade and legal status rather than by popularity.

More on Selank

DosageDoses used in published studies, with the source for each.CalculatorVial, water and dose to syringe units.Side effectsWhat labels and studies report, and what is unknown.ResultsStudy outcomes and when they were measured.PricePrice per mg and per week from dated listings. No vendor links.Legal statusFDA, compounding and WADA status with dates.

Sources

  1. 1[Effects of heptapeptide selank on genetically-based and situation-provoked symptoms of depression in behavior in WAG/Rij and Wistar rats, and in BALB/c mice].Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova · 2008PMID 18661785Accessed 2 Oct 2026

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