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Peptides for Diabetes

The peptides people most often research for diabetes, with how much evidence exists for each. A long list does not mean any of them is proven to work in people.

Medically reviewed by Juan Pablo Frías, MD · · DisclosureUpdated
Peptides listed
5
With human trials
5
FDA approved (any use)
3
Searches per month
1,190
Showing 5 peptides · ordered by search interest for this goal
  1. SemaglutideGLP-1 agonistHuman RCT evidence, 4 of 4The New England journal of medicine 2024, PMID 38785209Human1986Animal139Summarised5FDA approved (Ozempic, Wegovy, Rybelsus)For diabetesOverview
  2. TirzepatideGLP-1 / GIP dual agonistHuman RCT evidence, 4 of 4The New England journal of medicine 2025, PMID 41406444Human843Animal48Summarised8FDA approved (Mounjaro, Zepbound)For diabetesOverview
  3. MOTS-cMitochondrial-derived peptideHuman RCT evidence, 4 of 4Aging 2022, PMID 36490309Human25Animal16Summarised5PCAC voted 7–5 for 503A (Jul 2026)For diabetesOverview
  4. RetatrutideGLP-1 / GIP / glucagon triple agonistHuman RCT evidence, 4 of 4Lancet 2026, PMID 42810372Human53Animal6Summarised5Investigational · phase 3Overview
  5. HGHRecombinant growth hormoneHuman RCT evidence, 4 of 4The Journal of clinical endocrinology and metabolism 2003, PMID 12679422Human923Animal80Summarised1FDA approved (prescription only)Overview
Read this first

What this list does not show

Search demand tells you what people are curious about, not what works. Read each peptide's evidence before anything else.

Search interest is not evidence

This list follows what people search for and discuss. It says nothing about how well any peptide works.

Animal results may not carry over

Doses, routes and effects seen in rodents or cell dishes often have no tested human equivalent.

Approval covers specific uses

An FDA approval applies to the conditions and doses on the label, not to every goal a drug is searched with.

Combinations are a separate question

Blends and stacks put several peptides together. Evidence for one peptide is not evidence for the mix.
Related goals

Explore nearby goals

What people search

  • diabetes peptides590/mo
  • peptides for insulin resistance260/mo
  • best peptide for insulin resistance170/mo
  • best peptides for diabetes70/mo
  • insulin resistance peptides50/mo
  • best peptides for insulin resistance50/mo

US monthly searches, Google Keyword Planner, Oct 2026. Shown so you can see which questions this page answers.

Sources

  1. 1Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes.The New England journal of medicine · 2024PMID 38785209Accessed 2 Oct 2026
  2. 2Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes.The New England journal of medicine · 2025PMID 41406444Accessed 2 Oct 2026
  3. 3Circulating levels of MOTS-c in patients with breast cancer treated with metformin.Aging · 2022PMID 36490309Accessed 2 Oct 2026
  4. 4Retatrutide in adults with obesity and type 2 diabetes (TRIUMPH-2): a double-blind, parallel-group, randomised, placebo-controlled, phase 3 trial.Lancet (London, England) · 2026PMID 42810372Accessed 2 Oct 2026
  5. 5Growth hormone replacement therapy induces insulin resistance by activating the glucose-fatty acid cycle.The Journal of clinical endocrinology and metabolism · 2003PMID 12679422Accessed 2 Oct 2026

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