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Peptides for Liver health

The peptides people most often research for liver health, with how much evidence exists for each. A long list does not mean any of them is proven to work in people.

Medically reviewed by Juan Pablo Frías, MD · · DisclosureUpdated
Peptides listed
6
With human trials
4
FDA approved (any use)
4
Searches per month
1,490
Showing 6 peptides · ordered by search interest for this goal
  1. TirzepatideGLP-1 / GIP dual agonistHuman RCT evidence, 4 of 4The New England journal of medicine 2024, PMID 38856224Human143Animal15Summarised3FDA approved (Mounjaro, Zepbound)For liver healthOverview
  2. SemaglutideGLP-1 agonistHuman RCT evidence, 4 of 4The New England journal of medicine 2025, PMID 40305708Human305Animal59Summarised2FDA approved (Ozempic, Wegovy, Rybelsus)For liver healthOverview
  3. Kisspeptin-10GnRH stimulatorAnimal evidence, 2 of 4Cells 2025, PMID 40862768Human0Animal3Summarised3Not FDA approved · research chemicalFor liver healthOverview
  4. BPC-157Gastric pentadecapeptideAnimal evidence, 2 of 4Life sciences 2022, PMID 36228773Human3Animal22Summarised1PCAC voted 8–6 for 503A (Jul 2026)For liver healthOverview
  5. RetatrutideGLP-1 / GIP / glucagon triple agonistHuman RCT evidence, 4 of 4Nature medicine 2024, PMID 38858523Human18Animal4Summarised2Investigational · phase 3Overview
  6. TesamorelinGHRH analogHuman RCT evidence, 4 of 4The lancet. HIV 2019, PMID 31611038Human14Animal1Summarised1FDA approved (Egrifta)Overview
Read this first

What this list does not show

Search demand tells you what people are curious about, not what works. Read each peptide's evidence before anything else.

Search interest is not evidence

This list follows what people search for and discuss. It says nothing about how well any peptide works.

Animal results may not carry over

Doses, routes and effects seen in rodents or cell dishes often have no tested human equivalent.

Approval covers specific uses

An FDA approval applies to the conditions and doses on the label, not to every goal a drug is searched with.

Combinations are a separate question

Blends and stacks put several peptides together. Evidence for one peptide is not evidence for the mix.
Related goals

Explore nearby goals

What people search

  • peptides for liver health390/mo
  • peptide for fatty liver390/mo
  • liver peptides210/mo
  • peptides for liver140/mo
  • best peptide for liver health110/mo
  • best peptide for liver110/mo

US monthly searches, Google Keyword Planner, Oct 2026. Shown so you can see which questions this page answers.

Sources

  1. 1Tirzepatide for Metabolic Dysfunction-Associated Steatohepatitis with Liver Fibrosis.The New England journal of medicine · 2024PMID 38856224Accessed 2 Oct 2026
  2. 2Phase 3 Trial of Semaglutide in Metabolic Dysfunction-Associated Steatohepatitis.The New England journal of medicine · 2025PMID 40305708Accessed 2 Oct 2026
  3. 3Kisspeptin Mitigates Hepatic De Novo Lipogenesis in Metabolic Dysfunction-Associated Steatotic Liver Disease.Cells · 2025PMID 40862768Accessed 2 Oct 2026
  4. 4Pentadecapeptide BPC 157 efficiently reduces radiation-induced liver injury and lipid accumulation through Kruppel-like factor 4 upregulation both in vivo and in vitro.Life sciences · 2022PMID 36228773Accessed 2 Oct 2026
  5. 5Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial.Nature medicine · 2024PMID 38858523Accessed 2 Oct 2026
  6. 6Effects of tesamorelin on non-alcoholic fatty liver disease in HIV: a randomised, double-blind, multicentre trial.The lancet. HIV · 2019PMID 31611038Accessed 2 Oct 2026

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