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Peptides for Rheumatoid arthritis

The peptides people most often research for rheumatoid arthritis, with how much evidence exists for each. A long list does not mean any of them is proven to work in people.

Medically reviewed by Juan Pablo Frías, MD · · DisclosureUpdated
Peptides listed
7
With human trials
2
FDA approved (any use)
4
Searches per month
1,050
Showing 7 peptides · ordered by search interest for this goal
  1. SemaglutideGLP-1 agonistHuman RCT evidence, 4 of 4American heart journal 2025, PMID 40345413Human5Animal0Summarised2FDA approved (Ozempic, Wegovy, Rybelsus)For rheumatoid arthritisOverview
  2. TirzepatideGLP-1 / GIP dual agonistNo study with an outcome for rheumatoid arthritisPubMed search, 2 Oct 2026Human2Animal0Summarised1FDA approved (Mounjaro, Zepbound)For rheumatoid arthritisOverview
  3. KPVAnti-inflammatory tripeptideAnimal evidence, 2 of 4Inflammatory bowel diseases 2008, PMID 18092346Human1Animal0Summarised6PCAC voted 8–6 for 503A (Jul 2026)For rheumatoid arthritisOverview
  4. BPC-157Gastric pentadecapeptideAnimal evidence, 2 of 4Journal of physiology and pharmacology 2013, PMID 24304574Human1Animal0Summarised2PCAC voted 8–6 for 503A (Jul 2026)For rheumatoid arthritisOverview
  5. TB-500Synthetic fragment of thymosin beta-4Human RCT evidence, 4 of 4Microbial biotechnology 2021, PMID 34318587Human7Animal0Summarised2PCAC voted 8–6 for 503A (Jul 2026)Overview
  6. HGHRecombinant growth hormoneNo study with an outcome for rheumatoid arthritisPubMed search, 2 Oct 2026Human12Animal1Summarised0FDA approved (prescription only)Overview
  7. IpamorelinGHRP (ghrelin receptor agonist)No study with an outcome for rheumatoid arthritisPubMed search, 2 Oct 2026Human0Animal0Summarised0Not FDA approved · research chemicalOverview
Read this first

What this list does not show

Search demand tells you what people are curious about, not what works. Read each peptide's evidence before anything else.

Search interest is not evidence

This list follows what people search for and discuss. It says nothing about how well any peptide works.

Animal results may not carry over

Doses, routes and effects seen in rodents or cell dishes often have no tested human equivalent.

Approval covers specific uses

An FDA approval applies to the conditions and doses on the label, not to every goal a drug is searched with.

Combinations are a separate question

Blends and stacks put several peptides together. Evidence for one peptide is not evidence for the mix.
Related goals

Explore nearby goals

What people search

  • peptides for rheumatoid arthritis480/mo
  • best peptide for rheumatoid arthritis390/mo
  • rheumatoid arthritis peptides70/mo
  • best peptides for rheumatoid arthritis70/mo
  • peptide therapy for rheumatoid arthritis30/mo
  • peptide injections for rheumatoid arthritis10/mo

US monthly searches, Google Keyword Planner, Oct 2026. Shown so you can see which questions this page answers.

Sources

  1. 1Effect of once-weekly subcutaneous semaglutide on arterial inflammation in people with type 2 diabetes and cardiovascular disease using PET-MRI: Primary results of a randomized, double-blind, placebo-controlled trial.American heart journal · 2025PMID 40345413Accessed 2 Oct 2026
  2. 2Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease.Inflammatory bowel diseases · 2008PMID 18092346Accessed 2 Oct 2026
  3. 3Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability.Journal of physiology and pharmacology : an official journal of the Polish Physiological Society · 2013PMID 24304574Accessed 2 Oct 2026
  4. 4Recombinant human thymosin beta-4 (rhTβ4) improved scalp condition and microbiome homeostasis in seborrheic dermatitis.Microbial biotechnology · 2021PMID 34318587Accessed 2 Oct 2026
  5. 5PubMed search: tirzepatide[ti] AND (SURMOUNT[tiab] OR SURPASS[tiab]) AND randomized controlled trial[pt] (93 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  6. 6PubMed search: tirzepatide[ti] AND (SURPASS-2 OR SURPASS-3 OR SURPASS-4 OR SURPASS-5 OR "versus semaglutide" OR "SURPASS-CVOT" OR dulaglutide) (143 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  7. 7PubMed search: tirzepatide[ti] AND (steatohepatitis OR NASH OR "heart failure" OR HFpEF OR "preserved ejection" OR cardiovascular) (410 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  8. 8PubMed search: tirzepatide[ti] AND (SURPASS-2 OR SURPASS-3 OR SURPASS-1 OR SURPASS-5 OR "SURPASS J-mono") AND randomized controlled trial[pt] (24 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  9. 9PubMed search: tirzepatide[ti] AND (steatohepatitis OR "heart failure" OR "SUMMIT" OR "SYNERGY-NASH" OR "phase 2") AND randomized controlled trial[pt] (21 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  10. 10PubMed search: tirzepatide[tiab] AND (meta-analysis[pt] OR systematic review[pt]) AND (weight OR glycemic OR HbA1c OR obesity) (178 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  11. 11PubMed search: tirzepatide[tiab] AND (pharmacokinetic*[tiab] OR half-life[tiab]) AND humans[mh] (49 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  12. 12PubMed search: tirzepatide[ti] AND (insulin degludec OR "SURPASS-3") AND "type 2 diabetes"[ti] AND randomized controlled trial[pt] (8 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  13. 13PubMed search: tirzepatide[ti] AND (cardiovascular outcomes OR "SURPASS-CVOT" OR "major adverse") (228 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  14. 14PubMed search: tirzepatide[tiab] AND (depression OR anxiety OR ADHD OR osteoporosis OR "bone mineral" OR menopause OR "rheumatoid" OR arthritis OR testosterone) (121 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  15. 15PubMed search: tirzepatide[tiab] AND ("body composition"[tiab] OR "lean mass"[tiab] OR "visceral fat"[tiab] OR "fat mass"[tiab]) AND humans[mh] (91 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  16. 16PubMed search: tirzepatide[tiab] AND (blood pressure[tiab] OR cholesterol[tiab] OR lipid*[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt]) (58 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  17. 17PubMed search: tirzepatide[tiab] AND (SURPASS-CVOT OR "cardiovascular events" ) AND "dulaglutide"[tiab] AND randomized controlled trial[pt] (6 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  18. 18PubMed search: tirzepatide[tiab] AND (depression[tiab] OR anxiety[tiab] OR "mental health"[tiab] OR ADHD[tiab] OR "binge eating"[tiab]) AND (randomized controlled trial[pt] OR clinical trial[pt]) (3 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  19. 19PubMed search: tirzepatide[tiab] AND (menopaus*[tiab] OR PCOS[tiab] OR "polycystic"[tiab] OR testosterone[tiab] OR hypogonadism[tiab]) (55 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  20. 20PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND adult*[tiab] AND (meta-analysis[pt] OR systematic review[pt]) (68 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  21. 21PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND ("growth hormone deficiency"[tiab]) AND adult*[tiab] AND randomized controlled trial[pt] (66 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  22. 22PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND (elderly[tiab] OR "older adults"[tiab] OR healthy[tiab]) AND (systematic review[pt] OR meta-analysis[pt]) (8 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  23. 23PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND (athlet*[tiab] OR "physical performance"[tiab] OR "recreational"[tiab]) AND (randomized controlled trial[pt] OR systematic review[pt]) (20 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  24. 24PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND sleep[tiab] AND (randomized controlled trial[pt] OR clinical trial[pt]) (12 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  25. 25PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND (tendon[tiab] OR collagen[tiab] OR "wound healing"[tiab] OR fracture[tiab]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt]) (55 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  26. 26PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND (cardiovascular[tiab] OR cardiac[tiab] OR "blood pressure"[tiab] OR cholesterol[tiab] OR lipid*[tiab]) AND adult*[tiab] AND (meta-analysis[pt] OR systematic review[pt] OR randomized controlled trial[pt]) (77 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  27. 27PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND (diabetes[tiab] OR "insulin resistance"[tiab] OR glucose[tiab]) AND adult*[tiab] AND (meta-analysis[pt] OR systematic review[pt] OR randomized controlled trial[pt]) (52 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  28. 28PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND (skin[tiab] OR hair[tiab] OR aging[tiab]) AND (randomized controlled trial[pt] OR clinical trial[pt]) (30 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  29. 29PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND ("sexual function"[tiab] OR libido[tiab] OR "erectile"[tiab] OR "quality of life"[tiab]) AND adult*[tiab] AND (randomized controlled trial[pt] OR meta-analysis[pt]) (29 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  30. 30PubMed search: ipamorelin[tiab] (50 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  31. 31PubMed search: ipamorelin[tiab] AND (half-life[tiab] OR pharmacokinetic*[tiab]) (4 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026

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