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Does PT-141 make you tan?

The documented skin effect is focal hyperpigmentation, not general tanning. It was rare at labelled dosing but occurred in more than one-third of subjects after up to 16 consecutive daily doses.

Melanocortin agonistUpdated

Short answer

The documented skin effect is focal hyperpigmentation, not general tanning. It was rare at labelled dosing but occurred in more than one-third of subjects after up to 16 consecutive daily doses.[1]

What the label says

The label reports focal hyperpigmentation in 1% of patients and says the risk is higher with darker skin and with daily dosing.[2]

The label adds that resolution was not confirmed in some patients and advises considering stopping if hyperpigmentation develops.[2]

More questions on PT-141

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More on PT-141

Side effectsWhat labels and studies report, and what is unknown.PT-141 overview

Sources

  1. 1Safety Profile of Bremelanotide Across the Clinical Development Program.Journal of women's health (2002) · 2022PMID 35147466Accessed 2 Oct 2026
  2. 2VYLEESI prescribing information (FDA label)FDA label, DailyMed · current labeldailymed.nlm.nih.govAccessed 2 Oct 2026

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