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Kisspeptin-10 and hCG Together: What Is Known

Kisspeptin-10 and hCG taken together: what each one is, how each is regulated, and what is known about combining them.

Medically reviewed by Juan Pablo Frías, MD · · DisclosureUpdated
GnRH stimulatorNot FDA approved · research chemicalKisspeptin-10GnRH-stimulating peptide, not FDA-approved; in healthy men, subcutaneous kisspeptin-10 infusions dose-dependently raised LH, FSH and testosterone versus vehicle.[5]Sexual & hormonal healthGonadotropinFDA approved (prescription only)hCGGonadotropin FDA-approved for specific uses; the Novarel label states hCG has not been demonstrated to be effective adjunctive therapy in the treatment of obesity.[13]Other
Interaction notes

Timing, interactions and safety

Evidence for the combination

  • Animal study (stallions, donkeys, mules) giving kisspeptin-10, hCG and LH in separate groups and comparing testosterone responses. · PMID 28753433
  • Rhesus monkey study giving kisspeptin-10 and hCG challenges to the same animals. Animal data only. · PMID 18834893
The studies above describe research settings, not a recommendation to combine them. Ask the prescriber who manages both.
Each component

Side by side

Showing 9 of 12 fields where the two differ. PCAC vote, Jul 2026, WADA, Evidence strength are the same or both unknown.

FieldKisspeptin-10hCG
ClassGnRH stimulatorGonadotropin
Also calledkisshuman chorionic gonadotropin
CategorySexual & hormonal healthOther
FDA statusNot FDA approved · research chemicalFDA approved (prescription only)
Anti-doping detection
  • Kisspeptin-10 is cleared very fast (30 minutes in rats), so labs target metabolites.PMID 38978171
  • A 2026 method detects kisspeptins in serum and urine; samples from people who actually took them were not yet tested.PMID 42057309
None reportedanti-doping literature, as of 2 Oct 2026
Half-lifemean elimination half-life 1.3-2.2 hourssubcutaneous (analog MVT-602) · Fertility and sterility 2024, PMID 37925096pooled half-life 5.8 daysinjection (urinary and recombinant hCG) · Clinical endocrinology 2024, PMID 38446525
Human studies we summarised13 human (10 randomized or controlled) of 16 summarised10 human (9 randomized or controlled) of 15 summarised
Typical study doses
US searches per month22,200 · +371% searches74,000 · Flat YoY

What people search

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US monthly searches, Google Keyword Planner, Oct 2026. Shown so you can see which questions this page answers.

Sources

  1. 1World Anti-Doping Code International Standard Prohibited List 2026World Anti-Doping Agency · 2026wada-ama.orgAccessed 2 Oct 2026
  2. 2[Not Available].Biomedical chromatography : BMC · 2024PMID 38978171Accessed 2 Oct 2026
  3. 3Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography-High-Resolution Mass Spectrometry for Doping Control Purposes.Drug testing and analysis · 2026PMID 42057309Accessed 2 Oct 2026
  4. 4Endocrine profile of the kisspeptin receptor agonist MVT-602 in healthy premenopausal women with and without ovarian stimulation: results from 2 randomized, placebo-controlled clinical tricals.Fertility and sterility · 2024PMID 37925096Accessed 2 Oct 2026
  5. 5Chronic subcutaneous kisspeptin-10 stimulates gonadotropin secretion for 12 days in healthy men.European journal of endocrinology · 2026PMID 42549827Accessed 2 Oct 2026
  6. 6Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial.JAMA network open · 2022PMID 36287566Accessed 2 Oct 2026
  7. 7Single and multi-dose pharmacology of recombinant and urinary human chorionic gonadotrophin in men.Clinical endocrinology · 2024PMID 38446525Accessed 2 Oct 2026
  8. 8Effect of Combined Low Dose Human Gonadotropic Hormone, Follicle Stimulating Hormone, and Testosterone Therapy (LFT Regimen) Versus Conventional High Dose Human Gonadotropic Hormone and Follicle Stimulating Hormone on Spermatogenesis and Biomarkers in Men With Hypogonadotropic Hypogonadism.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2024PMID 39025301Accessed 2 Oct 2026
  9. 9Clomiphene citrate and human chorionic gonadotropin are both effective in restoring testosterone in hypogonadism: a short-course randomized study.BJU international · 2018PMID 29772111Accessed 2 Oct 2026
  10. 10PubMed search: (("human chorionic gonadotropin"[tiab] OR "chorionic gonadotropin"[tiab] OR "chorionic gonadotrophin"[tiab] OR hCG[tiab] OR choriogonadotropin[tiab]) NOT (pregnan*[tiab] OR trophoblast*[tiab] OR choriocarcinoma[tiab] OR "germ cell"[tiab] OR hydatidiform[tiab] OR "embryo transfer"[tiab] OR oocyte*[tiab] OR "in vitro fertilization"[tiab] OR IVF[tiab] OR "ovarian stimulation"[tiab] OR "ovulation induction"[tiab] OR "ovarian hyperstimulation"[tiab] OR equine[tiab] OR eCG[tiab] OR "pregnant mare"[tiab])) AND ("kisspeptin-10"[tiab] OR "kisspeptin 10"[tiab])PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  11. 11Effect of kisspeptin-10, LH and hCG on serum testosterone concentrations in stallions, donkeys and mules.Theriogenology · 2017PMID 28753433Accessed 2 Oct 2026
  12. 12Short-term fasting attenuates the response of the HPG axis to kisspeptin challenge in the adult male rhesus monkey (Macaca mulatta).Life sciences · 2008PMID 18834893Accessed 2 Oct 2026
  13. 13NOVAREL ® (chorionic gonadotropin) for injection, for intramuscular use Initial U.S. Approval: 1974FDA label, DailyMed · current labeldailymed.nlm.nih.govAccessed 2 Oct 2026

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