VIP Side Effects: What Studies and Users Report
What FDA labels and clinical studies report for VIP, how strong that evidence is, and what is still unknown.
Side effects reported in studies
Side effects reported in published studies, strongest design first. Frequencies are quoted as the source gives them; animal results are labelled.
| Side effect | How common | Study type | Source |
|---|---|---|---|
| No dropout from side effects | none | Human RCTn = 80 | Medical principles and practice 2025, PMID 39870064 |
| Death, serious adverse events, organ failure, serious infection or grade 3-4 adverse events up to day 5 | 146 of 231 (63%) vs 129 of 230 (56%) on placebo | Human RCTn = 461 | The Lancet. Respiratory medicine 2023, PMID 37348524 |
| Facial flushing | 69 patients (22.5%) | Human observationaln = 308 | The journal of sexual medicine 2025, PMID 40192471 |
| Ischemic priapism | one patient (0.3%) | Human observationaln = 308 | The journal of sexual medicine 2025, PMID 40192471 |
What is not known
- How common each effect is at the doses people use outside of studies.
- Effects that take longer to appear than the length of the published studies.
- How VIP interacts with other medicines and supplements.
- Whether research-grade products, which are not checked by the FDA, behave like the material used in studies.
When to get medical help
This is not a complete list. A doctor or pharmacist can help you judge whether a symptom is related.
Common questions
What are the side effects of VIP?
Studies we summarise reported no dropout from side effects, death, serious adverse events, organ failure, serious infection or grade 3-4 adverse events up to day 5, facial flushing. The table on this page gives how often each happened and links each source.
Is VIP safe?
VIP has an FDA-approved label that lists its known risks. That label covers the approved product used as prescribed, not compounded or research-chemical versions.
More on VIP
Sources
- 1Inhaled Aviptadil Is a New Hope for Recovery of Lung Damage due to COVID-19.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025PMID 39870064Accessed 2 Oct 2026
- 2Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial.The Lancet. Respiratory medicine · 2023PMID 37348524Accessed 2 Oct 2026
- 3Intracavernosal injection of aviptadil and phentolamine for refractory erectile dysfunction.The journal of sexual medicine · 2025PMID 40192471Accessed 2 Oct 2026
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