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Cagrilintide Side Effects: What Studies and Users Report

What FDA labels and clinical studies report for Cagrilintide, how strong that evidence is, and what is still unknown.

Medically reviewed by Juan Pablo Frías, MD · · DisclosureAmylin analogUpdated

Side effects reported in studies

Side effects reported in published studies, strongest design first. Frequencies are quoted as the source gives them; animal results are labelled.

Side effects of Cagrilintide in labels and published studies
Side effectHow commonStudy typeSource
No serious adverse events in impairment studies“In both studies, no serious TEAEs, TEAEs leading to study withdrawal or deaths were reported.”Frequency not statedHuman controlled trialClinical pharmacokinetics 2026, PMID 42228334
Gastrointestinal events and nausea41%-63% vs 32% with placebo; nausea 20%-47% vs 18%Human RCTLancet 2021, PMID 34798060
Adverse events (combined with semaglutide)“Most adverse events were mild to moderate in severity and the proportion of participants with one or more adverse event was similar across treatment groups.”Frequency not statedHuman RCTn = 96Lancet 2021, PMID 33894838

What is not known

  • How common each effect is at the doses people use outside of studies.
  • Effects that take longer to appear than the length of the published studies.
  • How Cagrilintide interacts with other medicines and supplements.
  • Whether research-grade products, which are not checked by the FDA, behave like the material used in studies.

When to get medical help

Get urgent care for: trouble breathing, swelling of the face or throat, a widespread rash, severe or lasting stomach pain, fainting, or an injection site that becomes hot, red and spreading.

This is not a complete list. A doctor or pharmacist can help you judge whether a symptom is related.

Common questions

What are the side effects of Cagrilintide?

Studies we summarise reported no serious adverse events in impairment studies, gastrointestinal events and nausea, adverse events (combined with semaglutide). The table on this page gives how often each happened and links each source.

Is Cagrilintide safe?

Its safety has not been established by an FDA review. Cagrilintide is investigational and not approved for any use. Research-chemical products are not checked for purity or dose.

Is Cagrilintide banned in sport?

Yes. Prohibited by WADA (S0). Tested athletes should not use it.

More on Cagrilintide

DosageDoses used in published studies, with the source for each.CalculatorVial, water and dose to syringe units.ResultsStudy outcomes and when they were measured.PricePrice per mg and per week from dated listings. No vendor links.Legal statusFDA, compounding and WADA status with dates.Half-lifeWhat is measured, by route, and what is not.

Sources

  1. 1Renal or Hepatic Impairment Does Not Affect Pharmacokinetics, Safety, or Tolerability of Subcutaneous Cagrilintide.Clinical pharmacokinetics · 2026PMID 42228334Accessed 2 Oct 2026
  2. 2Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial.Lancet (London, England) · 2021PMID 34798060Accessed 2 Oct 2026
  3. 3Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 2·4 mg for weight management: a randomised, controlled, phase 1b trial.Lancet (London, England) · 2021PMID 33894838Accessed 2 Oct 2026

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