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Peptides for Hormone balance

The peptides people most often research for hormone balance, with how much evidence exists for each. A long list does not mean any of them is proven to work in people.

Medically reviewed by Juan Pablo Frías, MD · · DisclosureUpdated
Peptides listed
5
With human trials
3
FDA approved (any use)
3
Searches per month
600
Showing 5 peptides · ordered by search interest for this goal
  1. SermorelinGHRH analogHuman RCT evidence, 4 of 4The Journal of clinical endocrinology and metabolism 1992, PMID 1379256Human2Animal0Summarised3Compounded by prescriptionOverview
  2. TirzepatideGLP-1 / GIP dual agonistHuman RCT evidence, 4 of 4Reproductive biology and endocrinology 2025, PMID 40604795Human6Animal4Summarised1FDA approved (Mounjaro, Zepbound)Overview
  3. CJC-1295GHRH analogHuman RCT evidence, 4 of 4The Journal of clinical endocrinology and metabolism 2006, PMID 16352683Human1Animal0Summarised2Not FDA approved · research chemicalOverview
  4. HGHRecombinant growth hormoneNo study with an outcome for hormone balancePubMed search, 2 Oct 2026Human385Animal83Summarised1FDA approved (prescription only)Overview
  5. GHK-CuCopper tripeptideNo study with an outcome for hormone balancePubMed search, 2 Oct 2026Human0Animal1Summarised0Injectable off Category 2 (Apr 2026)Overview
Read this first

What this list does not show

Search demand tells you what people are curious about, not what works. Read each peptide's evidence before anything else.

Search interest is not evidence

This list follows what people search for and discuss. It says nothing about how well any peptide works.

Animal results may not carry over

Doses, routes and effects seen in rodents or cell dishes often have no tested human equivalent.

Approval covers specific uses

An FDA approval applies to the conditions and doses on the label, not to every goal a drug is searched with.

Combinations are a separate question

Blends and stacks put several peptides together. Evidence for one peptide is not evidence for the mix.
Related goals

Explore nearby goals

What people search

  • peptides for hormone balance390/mo
  • peptides for estrogen50/mo
  • peptide for estrogen40/mo
  • estrogen peptides40/mo
  • best peptide for hormone balance40/mo
  • hormone balance peptides20/mo

US monthly searches, Google Keyword Planner, Oct 2026. Shown so you can see which questions this page answers.

Sources

  1. 1Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men.The Journal of clinical endocrinology and metabolism · 1992PMID 1379256Accessed 2 Oct 2026
  2. 2Short-term impact of tirzepatide on metabolic hypogonadism and body composition in patients with obesity: a controlled pilot study.Reproductive biology and endocrinology : RB&E · 2025PMID 40604795Accessed 2 Oct 2026
  3. 3Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.The Journal of clinical endocrinology and metabolism · 2006PMID 16352683Accessed 2 Oct 2026
  4. 4PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND adult*[tiab] AND (meta-analysis[pt] OR systematic review[pt]) (68 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  5. 5PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND ("growth hormone deficiency"[tiab]) AND adult*[tiab] AND randomized controlled trial[pt] (66 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  6. 6PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND (elderly[tiab] OR "older adults"[tiab] OR healthy[tiab]) AND (systematic review[pt] OR meta-analysis[pt]) (8 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  7. 7PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND (athlet*[tiab] OR "physical performance"[tiab] OR "recreational"[tiab]) AND (randomized controlled trial[pt] OR systematic review[pt]) (20 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  8. 8PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND sleep[tiab] AND (randomized controlled trial[pt] OR clinical trial[pt]) (12 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  9. 9PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND (tendon[tiab] OR collagen[tiab] OR "wound healing"[tiab] OR fracture[tiab]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt]) (55 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  10. 10PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND (cardiovascular[tiab] OR cardiac[tiab] OR "blood pressure"[tiab] OR cholesterol[tiab] OR lipid*[tiab]) AND adult*[tiab] AND (meta-analysis[pt] OR systematic review[pt] OR randomized controlled trial[pt]) (77 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  11. 11PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND (diabetes[tiab] OR "insulin resistance"[tiab] OR glucose[tiab]) AND adult*[tiab] AND (meta-analysis[pt] OR systematic review[pt] OR randomized controlled trial[pt]) (52 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  12. 12PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND (skin[tiab] OR hair[tiab] OR aging[tiab]) AND (randomized controlled trial[pt] OR clinical trial[pt]) (30 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  13. 13PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND ("sexual function"[tiab] OR libido[tiab] OR "erectile"[tiab] OR "quality of life"[tiab]) AND adult*[tiab] AND (randomized controlled trial[pt] OR meta-analysis[pt]) (29 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  14. 14PubMed search: ("GHK-Cu"[tiab] OR GHK[tiab] OR "copper tripeptide"[tiab] OR "copper peptide"[tiab] OR "copper peptides"[tiab] OR "glycyl-L-histidyl-L-lysine"[tiab] OR "glycyl-histidyl-lysine"[tiab] OR "Gly-His-Lys"[tiab]) (431 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  15. 15PubMed search: ("GHK-Cu"[tiab] OR GHK[tiab] OR "copper tripeptide"[tiab] OR "copper peptide"[tiab] OR "copper peptides"[tiab] OR "glycyl-L-histidyl-L-lysine"[tiab] OR "glycyl-histidyl-lysine"[tiab] OR "Gly-His-Lys"[tiab]) AND (humans[mh] OR patients[tiab] OR volunteers[tiab]) (150 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  16. 16PubMed search: ("GHK-Cu"[tiab] OR GHK[tiab] OR "copper tripeptide"[tiab] OR "copper peptide"[tiab] OR "copper peptides"[tiab] OR "glycyl-L-histidyl-L-lysine"[tiab] OR "glycyl-histidyl-lysine"[tiab] OR "Gly-His-Lys"[tiab]) AND (randomized[tiab] OR clinical trial[pt] OR split-face[tiab]) (8 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  17. 17PubMed search: ("GHK-Cu"[tiab] OR GHK[tiab] OR "copper tripeptide"[tiab] OR "copper peptide"[tiab] OR "copper peptides"[tiab] OR "glycyl-L-histidyl-L-lysine"[tiab] OR "glycyl-histidyl-lysine"[tiab] OR "Gly-His-Lys"[tiab]) AND (wound[tiab] OR hair[tiab] OR skin[tiab] OR wrinkle*[tiab]) (123 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  18. 18PubMed search: ("GHK-Cu"[tiab] OR GHK[tiab] OR "copper tripeptide"[tiab] OR "copper peptide"[tiab] OR "copper peptides"[tiab] OR "glycyl-L-histidyl-L-lysine"[tiab] OR "glycyl-histidyl-lysine"[tiab] OR "Gly-His-Lys"[tiab]) AND (half-life[tiab] OR pharmacokinetic*[tiab]) (2 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  19. 19PubMed search: ("GHK-Cu"[tiab] OR GHK[tiab] OR "copper tripeptide"[tiab] OR "copper peptide"[tiab] OR "copper peptides"[tiab] OR "glycyl-L-histidyl-L-lysine"[tiab] OR "glycyl-histidyl-lysine"[tiab] OR "Gly-His-Lys"[tiab]) AND (rat[tiab] OR mice[tiab] OR rats[tiab] OR animal[tiab]) (80 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  20. 20PubMed search: ("GHK-Cu"[tiab] OR "copper tripeptide"[tiab] OR "copper peptide"[tiab] OR "copper peptides"[tiab] OR "glycyl-L-histidyl-L-lysine"[tiab] OR "glycyl-histidyl-lysine"[tiab] OR "Gly-His-Lys"[tiab]) AND (facial[tiab] OR cream[tiab] OR photodamage[tiab] OR volunteers[tiab] OR women[tiab]) (6 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  21. 21PubMed search: ("GHK-Cu"[tiab] OR "copper tripeptide"[tiab] OR "copper peptide"[tiab] OR "copper peptides"[tiab] OR "glycyl-L-histidyl-L-lysine"[tiab] OR "glycyl-histidyl-lysine"[tiab] OR "Gly-His-Lys"[tiab]) AND (hair[tiab] OR alopecia[tiab]) (16 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026

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