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Peptides for Menopause

The peptides people most often research for menopause, with how much evidence exists for each. A long list does not mean any of them is proven to work in people.

Medically reviewed by Juan Pablo Frías, MD · · DisclosureUpdated
Peptides listed
8
With human trials
0
FDA approved (any use)
5
Searches per month
2,290
Showing 8 peptides · ordered by search interest for this goal
  1. SermorelinGHRH analogNo study with an outcome for menopausePubMed search, 2 Oct 2026Human0Animal0Summarised0Compounded by prescriptionFor menopauseOverview
  2. TirzepatideGLP-1 / GIP dual agonistNo study with an outcome for menopausePubMed search, 2 Oct 2026Human8Animal7Summarised0FDA approved (Mounjaro, Zepbound)For menopauseOverview
  3. IpamorelinGHRP (ghrelin receptor agonist)No study with an outcome for menopausePubMed search, 2 Oct 2026Human0Animal0Summarised0Not FDA approved · research chemicalFor menopauseOverview
  4. hCGGonadotropinNo study with an outcome for menopausePubMed search, 2 Oct 2026Human258Animal15Summarised0FDA approved (prescription only)Overview
  5. Kisspeptin-10GnRH stimulatorNo study with an outcome for menopausePubMed search, 2 Oct 2026Human3Animal1Summarised0Not FDA approved · research chemicalFor menopauseOverview
  6. BPC-157Gastric pentadecapeptideNo study with an outcome for menopausePubMed search, 2 Oct 2026Human0Animal0Summarised0PCAC voted 8–6 for 503A (Jul 2026)Overview
  7. MOTS-cMitochondrial-derived peptideAnimal evidence, 2 of 4Journal of molecular medicine 2019, PMID 30725119Human1Animal0Summarised2PCAC voted 7–5 for 503A (Jul 2026)Overview
  8. HGHRecombinant growth hormoneNo study with an outcome for menopausePubMed search, 2 Oct 2026Human61Animal1Summarised0FDA approved (prescription only)Overview
Read this first

What this list does not show

Search demand tells you what people are curious about, not what works. Read each peptide's evidence before anything else.

Search interest is not evidence

This list follows what people search for and discuss. It says nothing about how well any peptide works.

Animal results may not carry over

Doses, routes and effects seen in rodents or cell dishes often have no tested human equivalent.

Approval covers specific uses

An FDA approval applies to the conditions and doses on the label, not to every goal a drug is searched with.

Combinations are a separate question

Blends and stacks put several peptides together. Evidence for one peptide is not evidence for the mix.
Related goals

Explore nearby goals

What people search

  • peptides for menopause1,300/mo
  • best peptides for menopause480/mo
  • menopause peptides170/mo
  • peptides for menopausal women140/mo
  • best peptides for menopausal women70/mo
  • peptide therapy for menopause50/mo

US monthly searches, Google Keyword Planner, Oct 2026. Shown so you can see which questions this page answers.

Sources

  1. 1MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction.Journal of molecular medicine (Berlin, Germany) · 2019PMID 30725119Accessed 2 Oct 2026
  2. 2PubMed search: (sermorelin[tiab] OR Geref[tiab]) (34 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  3. 3PubMed search: (sermorelin[tiab] OR "GHRH(1-29)"[tiab] OR "GRF(1-29)"[tiab] OR "GHRH 1-29"[tiab]) AND (elderly[tiab] OR aging[tiab] OR "older adults"[tiab] OR adults[tiab]) AND (treatment[tiab] OR therapy[tiab] OR administration[tiab]) (15 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  4. 4PubMed search: (sermorelin[tiab] OR Geref[tiab]) AND (half-life[tiab] OR pharmacokinetic*[tiab]) (2 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  5. 5PubMed search: tirzepatide[ti] AND (SURMOUNT[tiab] OR SURPASS[tiab]) AND randomized controlled trial[pt] (93 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  6. 6PubMed search: tirzepatide[ti] AND (SURPASS-2 OR SURPASS-3 OR SURPASS-4 OR SURPASS-5 OR "versus semaglutide" OR "SURPASS-CVOT" OR dulaglutide) (143 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  7. 7PubMed search: tirzepatide[ti] AND (steatohepatitis OR NASH OR "heart failure" OR HFpEF OR "preserved ejection" OR cardiovascular) (410 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  8. 8PubMed search: tirzepatide[ti] AND (SURPASS-2 OR SURPASS-3 OR SURPASS-1 OR SURPASS-5 OR "SURPASS J-mono") AND randomized controlled trial[pt] (24 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  9. 9PubMed search: tirzepatide[ti] AND (steatohepatitis OR "heart failure" OR "SUMMIT" OR "SYNERGY-NASH" OR "phase 2") AND randomized controlled trial[pt] (21 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  10. 10PubMed search: tirzepatide[tiab] AND (meta-analysis[pt] OR systematic review[pt]) AND (weight OR glycemic OR HbA1c OR obesity) (178 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  11. 11PubMed search: tirzepatide[tiab] AND (pharmacokinetic*[tiab] OR half-life[tiab]) AND humans[mh] (49 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  12. 12PubMed search: tirzepatide[ti] AND (insulin degludec OR "SURPASS-3") AND "type 2 diabetes"[ti] AND randomized controlled trial[pt] (8 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  13. 13PubMed search: tirzepatide[ti] AND (cardiovascular outcomes OR "SURPASS-CVOT" OR "major adverse") (228 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  14. 14PubMed search: tirzepatide[tiab] AND (depression OR anxiety OR ADHD OR osteoporosis OR "bone mineral" OR menopause OR "rheumatoid" OR arthritis OR testosterone) (121 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  15. 15PubMed search: tirzepatide[tiab] AND ("body composition"[tiab] OR "lean mass"[tiab] OR "visceral fat"[tiab] OR "fat mass"[tiab]) AND humans[mh] (91 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  16. 16PubMed search: tirzepatide[tiab] AND (blood pressure[tiab] OR cholesterol[tiab] OR lipid*[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt]) (58 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  17. 17PubMed search: tirzepatide[tiab] AND (SURPASS-CVOT OR "cardiovascular events" ) AND "dulaglutide"[tiab] AND randomized controlled trial[pt] (6 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  18. 18PubMed search: tirzepatide[tiab] AND (depression[tiab] OR anxiety[tiab] OR "mental health"[tiab] OR ADHD[tiab] OR "binge eating"[tiab]) AND (randomized controlled trial[pt] OR clinical trial[pt]) (3 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  19. 19PubMed search: tirzepatide[tiab] AND (menopaus*[tiab] OR PCOS[tiab] OR "polycystic"[tiab] OR testosterone[tiab] OR hypogonadism[tiab]) (55 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  20. 20PubMed search: ipamorelin[tiab] (50 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  21. 21PubMed search: ipamorelin[tiab] AND (half-life[tiab] OR pharmacokinetic*[tiab]) (4 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  22. 22PubMed search: ("human chorionic gonadotropin"[tiab] OR hCG[tiab]) AND (hypogonadism[tiab] OR "male infertility"[tiab] OR hypogonadotropic[tiab] OR testosterone[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt]) (97 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  23. 23PubMed search: ("human chorionic gonadotropin"[tiab] OR hCG[tiab]) AND (obesity[tiab] OR "weight loss"[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt]) (11 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  24. 24PubMed search: ("human chorionic gonadotropin"[tiab] OR hCG[tiab]) AND (testosterone replacement[tiab] OR TRT[tiab] OR "anabolic steroid"[tiab] OR bodybuilder*[tiab] OR "lean body mass"[tiab] OR "muscle"[tiab]) AND humans[mh] (260 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  25. 25PubMed search: ("human chorionic gonadotropin"[tiab] OR hCG[tiab]) AND (half-life[tiab] OR pharmacokinetic*[tiab]) AND men[tiab] NOT pregnan*[tiab] (9 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  26. 26PubMed search: ("kisspeptin-10"[tiab] OR "kisspeptin 10"[tiab]) AND humans[mh] (110 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  27. 27PubMed search: (kisspeptin[tiab]) AND humans[mh] AND (randomized controlled trial[pt] OR clinical trial[pt]) (54 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  28. 28PubMed search: kisspeptin[tiab] AND (half-life[tiab] OR pharmacokinetic*[tiab]) AND humans[mh] (13 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  29. 29PubMed search: kisspeptin[tiab] AND humans[mh] AND (men[tiab] OR male[tiab]) AND (testosterone[tiab] OR hypogonadism[tiab]) (90 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  30. 30PubMed search: kisspeptin[tiab] AND (menopaus*[tiab] OR postmenopaus*[tiab]) (89 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  31. 31PubMed search: kisspeptin[tiab] AND (liver[tiab] OR NAFLD[tiab] OR hepatic[tiab]) (68 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  32. 32PubMed search: "BPC-157"[tiab] OR BPC157[tiab] OR "body protection compound"[tiab] OR "pentadecapeptide BPC"[tiab] (230 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  33. 33PubMed search: ("BPC-157"[tiab] OR BPC157[tiab] OR "body protection compound"[tiab]) AND (half-life[tiab] OR pharmacokinetic*[tiab]) (7 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  34. 34PubMed search: "BPC-157"[tiab] AND humans[mh] (52 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  35. 35PubMed search: ("BPC-157"[tiab] OR BPC157[tiab] OR "body protection compound"[tiab] OR "pentadecapeptide BPC"[tiab]) AND (patients[tiab] OR clinical trial[pt] OR randomized[tiab]) (25 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  36. 36PubMed search: ("BPC-157"[tiab] OR BPC157[tiab] OR "body protection compound"[tiab] OR "pentadecapeptide BPC"[tiab]) AND (colitis[tiab] OR inflammatory bowel[tiab]) (48 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  37. 37PubMed search: ("BPC-157"[tiab] OR BPC157[tiab] OR "body protection compound"[tiab] OR "pentadecapeptide BPC"[tiab]) AND (tendon[tiab] OR ligament[tiab] OR muscle[tiab] OR bone[tiab] OR arthritis[tiab]) (58 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  38. 38PubMed search: ("BPC-157"[tiab] OR BPC157[tiab] OR "body protection compound"[tiab] OR "pentadecapeptide BPC"[tiab]) AND (nerve[tiab] OR neuropath*[tiab] OR spinal[tiab] OR liver[tiab] OR wound[tiab] OR burn[tiab]) (90 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  39. 39PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND adult*[tiab] AND (meta-analysis[pt] OR systematic review[pt]) (68 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  40. 40PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND ("growth hormone deficiency"[tiab]) AND adult*[tiab] AND randomized controlled trial[pt] (66 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  41. 41PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND (elderly[tiab] OR "older adults"[tiab] OR healthy[tiab]) AND (systematic review[pt] OR meta-analysis[pt]) (8 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  42. 42PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND (athlet*[tiab] OR "physical performance"[tiab] OR "recreational"[tiab]) AND (randomized controlled trial[pt] OR systematic review[pt]) (20 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  43. 43PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND sleep[tiab] AND (randomized controlled trial[pt] OR clinical trial[pt]) (12 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  44. 44PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND (tendon[tiab] OR collagen[tiab] OR "wound healing"[tiab] OR fracture[tiab]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt]) (55 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  45. 45PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND (cardiovascular[tiab] OR cardiac[tiab] OR "blood pressure"[tiab] OR cholesterol[tiab] OR lipid*[tiab]) AND adult*[tiab] AND (meta-analysis[pt] OR systematic review[pt] OR randomized controlled trial[pt]) (77 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  46. 46PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND (diabetes[tiab] OR "insulin resistance"[tiab] OR glucose[tiab]) AND adult*[tiab] AND (meta-analysis[pt] OR systematic review[pt] OR randomized controlled trial[pt]) (52 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  47. 47PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND (skin[tiab] OR hair[tiab] OR aging[tiab]) AND (randomized controlled trial[pt] OR clinical trial[pt]) (30 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  48. 48PubMed search: (somatropin[tiab] OR "recombinant human growth hormone"[tiab] OR rhGH[tiab] OR "growth hormone replacement"[tiab] OR "growth hormone treatment"[tiab] OR "growth hormone therapy"[tiab]) AND ("sexual function"[tiab] OR libido[tiab] OR "erectile"[tiab] OR "quality of life"[tiab]) AND adult*[tiab] AND (randomized controlled trial[pt] OR meta-analysis[pt]) (29 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026

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