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Can retatrutide cause joint pain?

The cached trial abstract names gastrointestinal events as the most common adverse events and does not name joint pain in that sentence; joint pain in forum posts is only anecdotal.

GLP-1 / GIP / glucagon triple agonistUpdated

Short answer

The cached trial abstract names gastrointestinal events as the most common adverse events and does not name joint pain in that sentence; joint pain in forum posts is only anecdotal.[1]

Among adults with knee osteoarthritis in TRIUMPH-1, pain scores improved on retatrutide: -3.2, -3.5 and -3.6 across the dose groups versus -1.9 on placebo.[1]

How knee pain was measured in the trials

The TRIUMPH program tracked knee pain using the WOMAC pain subscale, a score for people who already have osteoarthritis rather than a screen for new joint pain.[2]

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Sources

  1. 1Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity.The New England journal of medicine · 2026PMID 42814954Accessed 2 Oct 2026
  2. 2Retatrutide for the treatment of obesity, obstructive sleep apnea and knee osteoarthritis: Rationale and design of the TRIUMPH registrational clinical trials.Diabetes, obesity & metabolism · 2026PMID 41090431Accessed 2 Oct 2026

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