How to Store Semaglutide: Refrigeration and Shelf Life
Whether Semaglutide needs refrigeration, how long powder and mixed vials keep, and what to do if a vial got warm.
For the FDA-approved product, the label and package insert are the authority on storage. The notes below are for vials of powder that are mixed before use.
Storage at a glance
Quoted from the FDA label, with the source for each row.
| Condition | What the source says | Source type | Source |
|---|---|---|---|
| Pen before first use | Prior to first use, the OZEMPIC pen should be stored in a refrigerator between 2°C to 8°C (36°F to 46°F). | FDA label | FDA label (Ozempic) |
| Pen after first use | After first use of the OZEMPIC pen, the pen can be stored for 56 days at controlled room temperature 15°C to 30°C (59°F to 86°F) or in a refrigerator 2°C to 8°C (36°F to 46°F). | FDA label | FDA label (Ozempic) |
| Freezing | Do not freeze OZEMPIC and do not use OZEMPIC if it has been frozen. | FDA label | FDA label (Ozempic) |
| Single-dose pen or syringe | Store the WEGOVY prefilled single-dose pen or single-dose syringe in the refrigerator from 2°C to 8°C (36°F to 46°F). | FDA label | FDA label (Wegovy) |
| Freezing | Do not freeze WEGOVY and do not use if it has been frozen. | FDA label | FDA label (Wegovy) |
| Tablets | Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) | FDA label | FDA label (Wegovy) |
| Tablets | Store RYBELSUS and OZEMPIC tablets at 20°C to 25°C (68°F to 77°F) | FDA label | FDA label (Rybelsus, Ozempic tablets) |
| Moisture | Store tablets in the original bottle until use to protect tablets from moisture. | FDA label | FDA label (Rybelsus, Ozempic tablets) |
Unmixed powder
Freeze-dried (lyophilized) powder is the form most vials ship in. Sourced conditions for Semaglutide are in the table above; anything they do not cover is unverified.
- Keep vials sealed, dry and out of direct light and heat until use.
- Check the label for a lot number and an expiry date. A vial with neither tells you nothing about its age.
After mixing
Once mixed with bacteriostatic water, peptide vials are usually kept in the refrigerator and used within a limited time. Sourced conditions for Semaglutide are in the table above; anything they do not cover is unverified.
- Write the mixing date on the vial.
- Swab the rubber top with alcohol before every draw.
- Do not freeze a mixed vial unless the product information says you can.
If it got warm or looks wrong
How much potency Semaglutide loses after a temperature slip is not covered by any published stability study we found. When in doubt, ask a pharmacist.
Common questions
Does Semaglutide need to be refrigerated?
Follow the storage instructions on the approved product's label (quoted on this page). Compounded or research versions should come with their own instructions; if they don't, ask the pharmacy.
How long is Semaglutide good for after mixing?
That depends on the product and how it was mixed. We publish a shelf life only from a manufacturer or a stability study; the sourced conditions are on this page.
More on Semaglutide
Sources
- 1These highlights do not include all the information needed to use OZEMPIC ® safely and effectively. See full prescribing information for OZEMPIC. OZEMPIC (semaglutide) injection, for subcutaneous use FDA label (Ozempic), DailyMed · current labeldailymed.nlm.nih.govAccessed 2 Oct 2026
- 2These highlights do not include all the information needed to use WEGOVY ® safely and effectively. See full prescribing information for WEGOVY. WEGOVY (semaglutide) injection, for subcutaneous use WEGFDA label (Wegovy), DailyMed · current labeldailymed.nlm.nih.govAccessed 2 Oct 2026
- 3These highlights do not include all the information needed to use RYBELSUS ® and OZEMPIC ® tablets safely and effectively. See full prescribing information for RYBELSUS and OZEMPIC tablets. RYBELSUS (FDA label (Rybelsus, Ozempic tablets), DailyMed · current labeldailymed.nlm.nih.govAccessed 2 Oct 2026
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