Does cagrilintide make you tired?
Fatigue was most common on the highest dose in the phase 2 weight-management trial: 20 of 101 in one cagrilintide arm against 3 of 101 in the pooled placebo group.
Amylin analogUpdated
Short answer
Fatigue was most common on the highest dose in the phase 2 weight-management trial: 20 of 101 in one cagrilintide arm against 3 of 101 in the pooled placebo group.[1]
That 20-of-101 arm is the 4.5 mg cagrilintide group.[1]
The comparison arm of 3 of 101 is the pooled placebo.[1]
Dose pattern and comparison
At the lower cagrilintide doses, fatigue counts were 8 of 101 and 5 of 100, and 8 of 99 on liraglutide.[1]
The trial abstract highlights gastrointestinal events, especially nausea, rather than fatigue, as the main tolerability finding.[2]
More questions on Cagrilintide
More on Cagrilintide
Sources
- 1Investigation of Safety and Efficacy of NNC0174-0833 for Weight Management - a Dose Finding Trial.ClinicalTrials.gov (U.S. National Library of Medicine) · 2019clinicaltrials.govAccessed 2 Oct 2026
- 2Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial.Lancet (London, England) · 2021PMID 34798060Accessed 2 Oct 2026
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