CJC-1295 + Ipamorelin for Hormone Balance: What the Evidence Shows
What human and animal studies show about CJC-1295 + Ipamorelin for hormone balance, how strong that evidence is, and what is still unproven.
- Strongest evidence
- Human RCT
- from an ingredient's studies
- Human studies
- 2
- with an outcome for hormone balance, in our evidence file (PubMed search, 11 Oct 2026)
- Animal studies
- None found
- with an outcome for hormone balance, in our evidence file (PubMed search, 11 Oct 2026)
- Studies we summarised
- 2
- with an outcome for hormone balance
Evidence for hormone balance
Each row is an outcome related to hormone balance from a published study, strongest design first. Animal and cell results are labelled and are not human results. User reports are not counted as evidence here. No study has tested CJC-1295 + Ipamorelin itself; rows are for each ingredient.
| Outcome | Result | Study type | Source |
|---|---|---|---|
| CJC-1295: GH and IGF-I | A single injection raised mean plasma GH 2- to 10-fold for 6 days or more and mean IGF-I 1.5- to 3-fold for 9-11 days, dose-dependently. | Human RCT | The Journal of clinical endocrinology and metabolism 2006, PMID 16352683 |
| CJC-1295: Repeat dosing | After multiple doses, mean IGF-I stayed above baseline for up to 28 days. | Human RCT | The Journal of clinical endocrinology and metabolism 2006, PMID 16352683 |
| CJC-1295: GH secretion pattern | Trough GH rose 7.5-fold, mean GH 46% and IGF-I 45% one week after a single injection, with GH pulsatility preserved. | Human uncontrolled trial | The Journal of clinical endocrinology and metabolism 2006, PMID 17018654 |
CJC-1295 + Ipamorelin and hormone balance are not in our PubMed count ledger yet; the rows above come from our evidence file (PubMed search, 11 Oct 2026). Grades follow our .
How strong is it?
A human randomized trial outweighs any number of animal studies. Animal and cell results show a mechanism worth testing, not that it works in people.
What hormones are, in the cached MedlinePlus text
MedlinePlus defines hormones as the body's chemical messengers, which travel in the bloodstream to tissues or organs.[3]
The hormones the two components were measured on
In healthy adults, subcutaneous CJC-1295 produced sustained, dose-dependent increases in GH and IGF-I, and the trial reported it as safe and relatively well tolerated.[1]
In healthy men a single CJC-1295 injection raised trough and mean GH and IGF-I with preserved pulsatility, a result for the CJC-1295 component only.[2]
In healthy male volunteers ipamorelin induced GH release at every dose level, a result for the ipamorelin component only.[4]
A proteomic study notes that current GH biomarkers show substantial variability in the population; it measured serum protein changes after CJC-1295, not sex hormones or thyroid hormones.[5]
Where the record stops
The cached evidence for this pair measures GH and IGF-I; across the 4 abstracts quoted on this page, the number that report oestrogen, progesterone, testosterone or thyroid outcomes is 0.
Calculated from abstracts checked 16352683, 17018654, 10496658, 19386527; sex or thyroid hormone outcomes reported 0. Formula: count of the checked abstracts reporting such outcomes = 0
The goal ledger holds no PubMed entry for this blend under hormone balance, so no human-only or animal-only count exists to cite.
Calculated from goal hormone-balance; peptide cjc-1295-ipamorelin. Formula: ledger entry = none in goals.json
Other peptides people research for hormone balance
All peptides for hormone balance, comparedCommon questions
Does CJC-1295 + Ipamorelin help with hormone balance?
The strongest study we summarise for hormone balance is human rct evidence, for an ingredient rather than the blend, across 2 studies with an outcome for hormone balance. A trial result is not an approval; see the legal status.
Is CJC-1295 + Ipamorelin approved for hormone balance?
No. CJC-1295 + Ipamorelin is not FDA approved for any use, including hormone balance.
What is the best peptide for hormone balance?
There is no single answer. Our hormone balance overview compares each candidate by evidence grade and legal status rather than by popularity.
Can CJC-1295 with ipamorelin balance hormones?
The only hormone changes in the cached trials are GH and IGF-I rises in healthy adults, shown for CJC-1295; no trial tested the blend for hormone balance.[1]
More on CJC-1295 + Ipamorelin
Sources
- 1Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.The Journal of clinical endocrinology and metabolism · 2006PMID 16352683Accessed 2 Oct 2026
- 2Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog.The Journal of clinical endocrinology and metabolism · 2006PMID 17018654Accessed 2 Oct 2026
- 3Official web pageOfficial web page · web page
- 4Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers.Pharmaceutical research · 1999PMID 10496658Accessed 2 Oct 2026
- 5Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2009PMID 19386527Accessed 2 Oct 2026
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