CJC-1295 for Hormone Balance: What the Evidence Shows
What human and animal studies show about CJC-1295 for hormone balance, how strong that evidence is, and what is still unproven.
- Strongest evidence
- Human RCT
- Human studies
- 1
- PubMed records, our ledger
- Animal studies
- 0
- PubMed records, our ledger
- Studies we summarised
- 2
- with an outcome for hormone balance
Evidence for hormone balance
Each row is an outcome related to hormone balance from a published study, strongest design first. Animal and cell results are labelled and are not human results. User reports are not counted as evidence here.
| Outcome | Result | Study type | Source |
|---|---|---|---|
| GH and IGF-I | A single injection raised mean plasma GH 2- to 10-fold for 6 days or more and mean IGF-I 1.5- to 3-fold for 9-11 days, dose-dependently. | Human RCT | The Journal of clinical endocrinology and metabolism 2006, PMID 16352683 |
| Repeat dosing | After multiple doses, mean IGF-I stayed above baseline for up to 28 days. | Human RCT | The Journal of clinical endocrinology and metabolism 2006, PMID 16352683 |
| GH secretion pattern | Trough GH rose 7.5-fold, mean GH 46% and IGF-I 45% one week after a single injection, with GH pulsatility preserved. | Human uncontrolled trial | The Journal of clinical endocrinology and metabolism 2006, PMID 17018654 |
PubMed records for CJC-1295 and hormone balance: 1 human, 0 animal (search counts, not studies we reviewed). Grades follow our .
How strong is it?
A human randomized trial outweighs any number of animal studies. Animal and cell results show a mechanism worth testing, not that it works in people.
Hormones, and what CJC-1295 trials measured
MedlinePlus calls hormones the body's chemical messengers, travelling in the bloodstream to tissues or organs.[3]
MedlinePlus warns that a tiny amount of a hormone can cause big changes, so too much or too little can be serious.[3]
CJC-1295 is a long-acting analog of growth hormone-releasing hormone, and its trials measured growth hormone and IGF-I concentrations.[1]
The hormone measurements in healthy adults
After a single injection, mean plasma GH rose 2- to 10-fold for 6 days or more and mean plasma IGF-I rose 1.5- to 3-fold for 9 to 11 days.[1]
After repeat doses, mean IGF-I stayed above baseline for up to 28 days.[1]
In healthy men, pulse frequency and size were unaltered while basal GH rose 7.5-fold and mean GH rose 46%.[2]
A serum-protein study in young men found an apolipoprotein A1 isoform and a transthyretin isoform decreased after treatment.[4]
Who the data covers, and the cautions
The healthy-adult authors reported no serious adverse reactions.[1]
A study of forum threads on female CJC-1295 use records concerns that gender differences in growth hormone pulses affect dose estimation, cycling and long-term consequences; this is forum-based, not trial data.[5]
A review lists prolactin and cortisol elevations, appetite changes and dysglycaemia among adverse effects reported with these peptides.[6]
How much hormone-balance research exists
A PubMed search of CJC-1295 with hormone-balance terms (2026-10-02) found 1 human-only papers and 0 under the animal filter; 0 carried a randomized-trial tag.
Calculated from pubmed query ("CJC-1295"[tiab] OR CJC1295[tiab]) AND (estrogen*[tiab] OR oestrogen*[tiab] OR estradiol[tiab] OR oestradiol[tiab] OR progesterone[tiab] OR "sex hormone"[tiab] OR "sex hormones"[tiab] OR "hormone balance"[tiab] OR "hormonal balance"[tiab] OR "hormonal imbalance"[tiab]); date 2026-10-02; human only count 1; animal filter count 0; randomized filter count 0. Formula: counts as recorded in the goals.json ledger (PubMed [tiab] query with the human-only, animal and RCT filters shown)
Other peptides people research for hormone balance
All peptides for hormone balance, comparedCommon questions
Does CJC-1295 help with hormone balance?
The strongest study we summarise for hormone balance is human rct evidence, across 2 studies with an outcome for hormone balance. A trial result is not an approval; see the legal status.
Is CJC-1295 approved for hormone balance?
No. CJC-1295 is not FDA approved for any use, including hormone balance.
What is the best peptide for hormone balance?
There is no single answer. Our hormone balance overview compares each candidate by evidence grade and legal status rather than by popularity.
Does CJC-1295 balance hormones?
In healthy adults it raised growth hormone and IGF-I concentrations; the trials did not set out to correct any hormone imbalance.[1]
Is CJC-1295 safe for hormone levels in women?
The only female-specific source in the cached files is a forum-based study, which records concerns about dosing and long-term consequences rather than measuring them.[5]
More on CJC-1295
Sources
- 1Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.The Journal of clinical endocrinology and metabolism · 2006PMID 16352683Accessed 2 Oct 2026
- 2Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog.The Journal of clinical endocrinology and metabolism · 2006PMID 17018654Accessed 2 Oct 2026
- 3Official web pageOfficial web page · web page
- 4Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2009PMID 19386527Accessed 2 Oct 2026
- 5Netnography of Female Use of the Synthetic Growth Hormone CJC-1295: Pulses and Potions.Substance use & misuse · 2016PMID 26771670Accessed 2 Oct 2026
- 6The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.Frontiers in endocrinology · 2026PMID 42395176Accessed 2 Oct 2026
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