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Does retatrutide burn visceral fat?

A review states that glucagon-containing agents including retatrutide preferentially reduce visceral and liver fat, citing liver-fat falls of roughly 60-80%; this is a review statement, not a visceral-fat trial result.

GLP-1 / GIP / glucagon triple agonistUpdated

Short answer

A review states that glucagon-containing agents including retatrutide preferentially reduce visceral and liver fat, citing liver-fat falls of roughly 60-80%; this is a review statement, not a visceral-fat trial result.[1]

What trials actually measured

In the liver substudy, liver-fat falls were related to changes in abdominal fat as well as body weight.[2]

The body-composition substudy measured total fat mass by DXA at 36 weeks, not visceral fat specifically.[3]

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More on Retatrutide

ResultsStudy outcomes and when they were measured.Retatrutide overview

Sources

  1. 1Anti-Obesity Medications in Longevity and Aesthetic Medicine.Journal of clinical medicine · 2026PMID 42590128Accessed 2 Oct 2026
  2. 2Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial.Nature medicine · 2024PMID 38858523Accessed 2 Oct 2026
  3. 3Effects of retatrutide on body composition in people with type 2 diabetes: a substudy of a phase 2, double-blind, parallel-group, placebo-controlled, randomised trial.The lancet. Diabetes & endocrinology · 2025PMID 40609566Accessed 2 Oct 2026

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