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Does retatrutide cause bloating?

Bloating is not named in this abstract, but gut-related events were the most common adverse events in the phase 2 obesity trial, rose with dose, and were partly lessened by a lower starting dose.

GLP-1 / GIP / glucagon triple agonistUpdated

Short answer

Bloating is not named in this abstract, but gut-related events were the most common adverse events in the phase 2 obesity trial, rose with dose, and were partly lessened by a lower starting dose.[1]

The mid-stage diabetes abstract lists nausea, diarrhoea, vomiting and constipation as examples of gut events and does not mention bloating.[2]

In the phase 3 diabetes trial, diarrhoea and nausea were both clearly more common on retatrutide than on placebo, with rates rising as the dose rose.[3]

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Sources

  1. 1Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial.The New England journal of medicine · 2023PMID 37366315Accessed 2 Oct 2026
  2. 2Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA.Lancet (London, England) · 2023PMID 37385280Accessed 2 Oct 2026
  3. 3Retatrutide in adults with obesity and type 2 diabetes (TRIUMPH-2): a double-blind, parallel-group, randomised, placebo-controlled, phase 3 trial.Lancet (London, England) · 2026PMID 42810372Accessed 2 Oct 2026

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