Does retatrutide cause hair loss?
A review covering semaglutide, tirzepatide and retatrutide says hair loss has emerged as an adverse event in clinical practice, but the retatrutide trial abstracts we hold name stomach and bowel problems as the most common side effects, not hair loss.
Short answer
A review covering semaglutide, tirzepatide and retatrutide says hair loss has emerged as an adverse event in clinical practice, but the retatrutide trial abstracts we hold name stomach and bowel problems as the most common side effects, not hair loss.[1]
In the large phase 3 obesity trial, the abstract names gastrointestinal events as the most common adverse events and does not single out hair loss.[2]
What a review covering retatrutide found
The review covers semaglutide, tirzepatide and retatrutide together, and puts hair loss at 3 to 7% in controlled trials against over 70% in real-world cohorts, so the figures are not retatrutide-only.[1]
The shedding it describes is mostly telogen effluvium, which the review links to how large and how fast the weight loss is rather than to toxicity of the drug.[1]
Being female and losing more than 10% of body weight were the strongest predictors of hair loss in that review.[1]
The authors call the hair loss mostly transient and reversible, while noting that the distress it causes can lead people to stop treatment.[1]
More questions on Retatrutide
More on Retatrutide
Sources
- 1GLP-1 receptor agonists and hair loss: adverse effect, epiphenomenon, or therapeutic paradox?Acta diabetologica · 2026PMID 42873315Accessed 29 Oct 2026
- 2Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity.The New England journal of medicine · 2026PMID 42814954Accessed 2 Oct 2026
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