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Does retatrutide cause headaches?

The trial abstracts do not name headache. In the phase 2 obesity registry, headache affected 0 of 70 placebo participants and 4 of 62 in the top-dose step-up arm.

GLP-1 / GIP / glucagon triple agonistUpdated

Short answer

The trial abstracts do not name headache. In the phase 2 obesity registry, headache affected 0 of 70 placebo participants and 4 of 62 in the top-dose step-up arm.[1]

The placebo arm of the phase 2 obesity trial is listed as EG000 in its registry results.[1]

The registry results label the 12 mg arm of the phase 2 obesity trial, begun at 2 mg, as EG006.[1]

Second phase 2 trial

In the phase 2 type 2 diabetes registry, headache affected 2 of 45 placebo participants and 1 of 46 in the top-dose step-up arm, so no clear dose pattern shows.[2]

Registry arm EG007 of the diabetes phase 2 trial received 2 mg first and 12 mg last.[2]

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Sources

  1. 1A Phase 2 Study of Once-Weekly LY3437943 Compared With Placebo in Participants Who Have Obesity or Are Overweight With Weight-Related ComorbiditiesClinicalTrials.gov (U.S. National Library of Medicine) · 2021clinicaltrials.govAccessed 2 Oct 2026
  2. 2A Phase 2 Study of Once-Weekly LY3437943 Compared With Placebo and Dulaglutide in Participants With Type 2 DiabetesClinicalTrials.gov (U.S. National Library of Medicine) · 2021clinicaltrials.govAccessed 2 Oct 2026

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