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Does retatrutide cause heartburn?

Reflux was more common at the top dose. In the obesity dose-finding registry, gastro-oesophageal reflux disease affected 1 of 70 on placebo and 4 of 62 in the top-dose step-up arm.

GLP-1 / GIP / glucagon triple agonistUpdated

Short answer

Reflux was more common at the top dose. In the obesity dose-finding registry, gastro-oesophageal reflux disease affected 1 of 70 on placebo and 4 of 62 in the top-dose step-up arm.[1]

Dyspepsia in the same registry affected 2 of 70 on placebo and 5 of 62 in the top-dose arm.[1]

In the diabetes registry, dyspepsia affected 0 of 45 on placebo and 3 of 46 in the top-dose step-up arm.[2]

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Sources

  1. 1A Phase 2 Study of Once-Weekly LY3437943 Compared With Placebo in Participants Who Have Obesity or Are Overweight With Weight-Related ComorbiditiesClinicalTrials.gov (U.S. National Library of Medicine) · 2021clinicaltrials.govAccessed 2 Oct 2026
  2. 2A Phase 2 Study of Once-Weekly LY3437943 Compared With Placebo and Dulaglutide in Participants With Type 2 DiabetesClinicalTrials.gov (U.S. National Library of Medicine) · 2021clinicaltrials.govAccessed 2 Oct 2026

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